In this report, we present a case that developed anaphylaxis to cow's milk as early as the first week of orthotopic liver transplantation under tacrolimus immunosuppression. This is the earliest case of transplant-acquired food allergy without any evidence of passive transfer of donor's specific IgE.
Get full access to this article
View all access options for this article.
References
1.
BoyleR, HardikarW, TangM. The development of food allergy after liver transplantation. Liver Transpl, 2005; 11:326–330.
2.
LacailleF, LaurentJ, BousquetJ. Life-threatening food allergy in a child treated with FK506. J Pediatr Gastroenterol Nutr, 1997; 25:228–229.
3.
LevyY, DavidovitsM, CleperR, ShapiroR. New-onset post-transplantation food allergy in children-is it attributable only to the immunosuppressive protocol?Pediatr Transplant, 2009; 13:63–69.
4.
NobleC, PeakeJ, LewindonPJ. Increase in de novo allergies after paediatric liver transplantation: the Brisbane experience. Pediatr Transplant, 2011; 15:451–454.
5.
OzbekOY, OzcayF, AvciZ, HaberalA, HaberalM. Food allergy after liver transplantation in children: a prospective study. Pediatr Allergy Immunol, 2009; 20:741–747.
6.
LykavierisP, FraugerE, HabesD, BernardO, DebrayD. Angioedema in pediatric liver transplant recipients under tacrolimus immunosuppression. Transplantation, 2003; 75:152–155.
7.
LegendreC, Caillat-ZucmanS, SamuelDet al.Transfer of symptomatic peanut allergy to the recipient of a combined liver and kidney transplant. N Engl J Med, 1997; 337:822–824.
8.
TrotterJF, EversonGT, BockSA, WachsM, BakT, KamI. Transference of peanut allergy through liver transplantation. Liver Transpl, 2001; 7:1088–1089.
9.
Nowak-WegrzynAH, SichererSH, Conover-WalkerMK, WoodRA. Food allergy after pediatric organ transplantation with tacrolimus immunosuppression. J Allergy Clin Immunol, 2001; 108:146.
10.
GabeSM, BjarnasonI, Tolou-GamariZet al.The effect of tacrolimus (FK506) on intestinal barrier function and cellular energy production in humans. Gastroenterology, 1998; 115:67.
11.
KleinSC, KubeD, AbtsH, DiehlV, TreschH. Promotion of IL8, IL10, TNF alpha and TNF beta production by EBV infection. Leuk Res, 1996; 20:633–636.
12.
OhnishiE, IwataT, InouyeS, KurataT, SairenjiT. Interleukin-4 production in Epstein–Barr virus-transformed B cell lines from peripheral mononuclear cells of patients with atopic dermatitis. J Interferon Cytokine Res, 1997; 17:597–602.
13.
HendersonDJ, NayaI, BundickRV, SmithGM, SchmidtJA. Comparison of the effects of FK-506, cyclosporin A and rapamycin on IL-2 production. Immunology, 1991; 73:316–321.
14.
DumontFJ, StaruchMJ, FischerP, DasilvaC, CamachoR. Inhibition of T cell activation by pharmacologic disruption of the MEK1/ERK MAP kinase or calcineurin signaling pathways results in differential modulation of cytokine production. J Immunol, 1998; 160:2579–2589.
15.
GranotE, YakobovichE, BardensteinR. Tacrolimus immunosuppression-an association with asymptomatic eosinophilia and elevated total and specific IgE levels. Pediatr Transplantation, 2006; 10:690–693.
16.
BarnesEJ, Abdel-RehimMM, GoulisYet al.Applications and limitations of blood eosinophilia for the diagnosis of acute cellular rejection in liver transplantation. Am J Transplant, 2003; 3:432–438.
17.
KawamuraN, FurutaH, TameAet al.Extremely high serum level of IgE during immunosuppressive therapy: paradoxical effect of cyclosporine and tacrolimus. Int Arch Allergy Immunol, 1997; 112:422–424.
18.
WisniewskiJ, LiebermanJ, Nowak-WęgrzynAet al.De novo food sensitization and eosinophilic gastrointestinal disease in children post-liver transplantation. Clin Transplant, 2012; 26:365–371.
