Abstract
Bacteria can exist in two different forms: a free floating or planktonic form, or a biofilm form. Biofilms are bacteria organized in structured communities enmeshed in an exopolysaccharide matrix and adherent to inert or living surfaces. Bacteria in biofilms have distinct properties from planktonic bacteria, most importantly being their resistance to antimicrobials, which is a multifactorial process. Biofilms have been implicated in several infections, including chronic rhinosinusitis, although there is a paucity of large-scale studies to demonstrate the true role of biofilms in this disease. More studies are needed to understand the nature of biofilms on a cellular and molecular level which may help us with potential targeted therapy.
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