A 10-Year-Old with Chronic Cough

Abstract

We report on a 10-year-old male with chronic cough, recurrent sinusitis, and perennial rhinitis that was not responsive to primary intervention. Sweat chloride values were normal and computed tomography (CT) of the chest revealed bilateral bronchiectasis. Sputum cultures had heavy growth of Staphylococcus aureus. Cystic fibrosis transmembrane conductance regulator (CFTR) sequencing demonstrated Delta F508 and D579G mutations, thereby identifying cystic fibrosis in this patient. Pancreatic sufficiency was demonstrated by normal fecal pancreatic elastase-1 levels. This case report highlights the investigation of a chronic cough, briefly reviews cystic fibrosis, and provides further evidence of the D579G mutation conferring a pancreatic sufficient state. (Pediatr Asthma Allergy Immunol 2006; 19[1]:36–43.)