Abstract
The proliferative responses of peripheral blood mononuclear cells (PBMCs) to house dust or mites in patients with bronchial asthma tended to be higher or were significantly higher, respectively, than responses in healthy controls. Interestingly, there was a large distribution of the proliferative responses in the asthmatic group. This large distribution may be caused by increased in vivo sensitization of lymphocytes to the allergens. Therefore, proliferative responses of PBMCs to house dust or mites are useful for detecting the magnitude of in vivo sensitization of lymphocytes to the allergens in patients with bronchial asthma.
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