Abstract
Sodium cromoglycate (SCG) was given daily for 24 weeks to 13 children with bronchial asthma, and its acute and chronic actions were determined. SCG was found to increase the peak expiratory flow rate (PEFR) immediately after inhalation in 12 patients, an increase frequently observed in patients whose PEFR was less than 50% of the expected value. In addition, the mean PEFR was increased by 17% after the study compared with that deduced from the baseline before the study, and the difference was statistically significant. These results indicate both acute and chronic antagonistic effects of SCG for bronchoconstriction in childhood asthma.
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