Abstract
ABSTRACT
Interferon-γ (IFN-γ) concentrations in culture supernatants of ovalbumin (OA)-stimulated peripheral blood mononuclear cells (PBMCs) from hen's-egg–sensitive patients with atopic dermatitis (AD) were significantly higher than those of healthy children. Our previous study shows that CD4+ T cells responded well to OA or in hen's-egg–sensitive AD. These results suggest that, in patients with AD who are sensitive to food, the CD4+ T lymphocytes stimulated by food antigens clearly secrete lymphokines such as IFN-γ that are secreted from TH1 clones in mice. IFN-γ may play an important role in food-sensitive AD. Furthermore, in this study, azelastine suppressed IFN-γ production of PBMCs stimulated with OA in patients with hen's-egg–sensitive AD. In conclusion, our results suggest that azelastine can be clinically applied to patients with food-sensitive AD.
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