Abstract
Rapid advances in elucidating the underlying defects of various primary immunodeficiencies have been made using the complementary approaches of cellular and molecular biology, e.g., X-linked chronic granulomatous disease and leukocyte adhesion deficiency. The present review summarizes the clinical features, treatment and prognosis, cellular defects, and genetic aspects of the four X-linked immunodeficiencies involving the lymphoid system, X-linked agammaglobulinemia, X-linked severe combined immunodeficiency, Wiskott-Aldrich syndrome, and X-linked hyperimmunoglobulinemia M.
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