Abstract
Hammerhead ribozymes and stable stem loop structures function as inhibitors of 3‵-5‵-exonuclease degradation of external guide sequences (EGSs) when covalently linked to the 3‵-end of EGS RNAs. This observation may be of use in improving the efficiency of gene inactivation techniques that use single-stranded RNA (e.g., antisense RNA, EGS RNA) in vivo.
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