Abstract
The Rosalind Franklin Society (RFS), in partnership with Mary Ann Liebert, Inc., publishers, enthusiastically congratulate our distinguished recipient of the 2024 annual
Anne Caroline Rodrigues dos Santos, Renata Pereira Laurindo, Fernanda Marques Pestana, Luiza dos Santos Heringer, Nathalie Henrique Silva Canedo, Ana Maria Blanco Martinez, and Suelen Adriani Marques, “Exercise Volume Can Modulate the Regenerative Response to Spinal Cord Injury in Mice,” Neurotrauma Reports 5, No. 1 (2024): 721–737, https://doi.org/10.1089/neur.2024.0023.
Abstract
Traumatic spinal cord injury (SCI) causes debilitating motor and sensory deficits that impair functional performance, and physical rehabilitation is currently the only established therapeutic reality in the clinical setting. In this study, we aimed to assess the effect of exercise of different volume and timing of intervention on functional recovery and neuromuscular regeneration in a mouse model of compressive SCI. Mice were assigned to one of four groups: laminectomy only (SHAM); injured, without treadmill training (SCI); injured, treadmill trained for 10 min until day 56 postinjury (TMT1); and injured, treadmill trained for two 10-min cycles with a 10-min pause between them until day 28 postinjury followed by the TMT1 protocol until day 56 postinjury (TMT3). On day 7 postinjury, animals started an eight-week treadmill-training exercise protocol and were trained three times a week. TMT3 mice had the best results in terms of neuroregeneration, functional recovery, and muscle plasticity as measured by functional and morphometric parameters. In conclusion, the volume of exercise can modulate the quality of the regenerative response to injury, when started in the acute phase and adjusted according to the inflammatory window.
Biosketch
Dr. Anne Caroline Rodrigues dos Santos was born in Alagoas state, Brazil. She studied at Federal University of Rio de Janeiro and completed her degree in Nursing. She works with neuroscience for 12 years. Dr. Santos holds a MsC (2019) and a PhD (2024) in Sciences at UFRJ. She completed her master's degree with focus on traumatic spinal cord injury and treadmill exercise, verifying the effect of exercise protocols with different intensities on functional recovery and neuromuscular regeneration in a model of compressive spinal cord injury. Later, in doctorate, she analyzed the influence of an exercise protocol on the modulation of the inflammatory microenvironment of the injury, neuroplasticity and sensorimotor recovery, after compressive spinal cord injury in mice. She is currently a researcher at the Laboratory of Neurodegeneration and Repair, at the Federal University of Rio de Janeiro, headed by Dr. Ana Martinez. She was a professor at UFRJ and Centro Universitário de Valença. She currently works as a professor at the Faculty of Medical Sciences of Três Rios and is a speaker at several national and international scientific conferences.