After a traumatic brain injury (TBI), many persons experience significant and debilitating problems with anxiety. The aim of this systematic review was to critically evaluate the evidence regarding efficacy of pharmacological interventions for anxiety after TBI. We reviewed studies published in English before July 2020 and included original research on pharmacological interventions for anxiety after TBI in adults ≥16 years of age. MEDLINE, PubMed, CINAHL, EMBASE, PsycINFO, and CENTRAL databases were searched, with additional searching of key journals, clinical trials registries, and international drug regulators. The primary outcomes of interest were reduction in symptoms of anxiety and occurrence of harms. The secondary outcomes of interest were changes in depression, cognition, quality of life, and participation. Data were summarized in a narrative synthesis, and evidence quality was assessed using the Cochrane Risk of Bias tool. Only a single non-peer-reviewed, randomized controlled trial of 19 male military service members with mild TBI met inclusion criteria. This study found no significant effect of citalopram on anxiety symptoms over a 12-week intervention. The trial was stopped early because of poor recruitment, and much of the study detail was not included in the report. The methodological quality of the study was difficult to assess because of the lack of detail. No recommendations could be drawn from this review. There is a critical need for adequately powered and controlled studies of pharmacological interventions for anxiety after TBI across all severities that examine side-effect profiles and consider issues of comorbidity and effects of long-term pharmacotherapy.
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References
1.
Whelan-GoodinsonR., PonsfordJ., JohnstonL., and GrantF. (2009). Psychiatric disorders following traumatic brain injury: their nature and frequency. J. Head Trauma Rehabil. 24, 324–332.
2.
GouldK.R., PonsfordJ.L., JohnstonL., and SchonbergerM. (2011). The nature, frequency and course of psychiatric disorders in the first year after traumatic brain injury: a prospective study. Psychol. Med. 41, 2099–2109.
3.
van ReekumR., BolagoI., FinlaysonM.A., GarnerS., and LinksP.S. (1996). Psychiatric disorders after traumatic brain injury. Brain Inj. 10, 319–327.
4.
AshmanT.A., SpielmanL.A., HibbardM.R., SilverJ.M., ChandnaT., and GordonW.A. (2004). Psychiatric challenges in the first 6 years after traumatic brain injury: cross-sequential analyses of Axis I disorders. Arch. Phys. Med. Rehabil. 85, 4 Suppl. 2, S36–S42.
5.
DiazA.P., SchwarzboldM.L., ThaisM.E., HohlA., BertottiM.M., SchmoellerR., NunesJ.C., PredigerR., LinharesM.N., GuarnieriR., and WalzR. (2012). Psychiatric disorders and health-related quality of life after severe traumatic brain injury: a prospective study. J. Neurotrauma, 29, 1029–1037.
6.
OsbornA.J., MathiasJ.L., and Fairweather-SchmidtA.K. (2016). Prevalence of anxiety following adult traumatic brain injury: a meta-analysis comparing measures, samples and postinjury intervals. Neuropsychology, 30, 247–261.
7.
ScholtenA.C., HaagsmaJ.A., CnossenM.C., OlffM., van BeeckE.F., and PolinderS. (2016). Prevalence of and risk factors for anxiety and depressive disorders after traumatic brain injury: a systematic review. J. Neurotrauma, 33, 1969–1994.
8.
AlwayY., GouldK.R., JohnstonL., McKenzieD., and PonsfordJ. (2016). A prospective examination of Axis I psychiatric disorders in the first 5 years following moderate to severe traumatic brain injury. Psychol. Med. 46, 1331–1341.
9.
CaplanB., BognerJ., BrennerL., AlbrechtJ.S., PetersM.E., SmithG.S., and RaoV. (2017). Anxiety and posttraumatic stress disorder among medicare beneficiaries after traumatic brain injury. J. Head Trauma Rehabil. 32, 178–184.
10.
AbdullahM.F.I.L.B., NgY.P., and SidiH.B. (2018). Depression and anxiety among traumatic brain injury patients in Malaysia. Asian J. Psychiatr. 37, 67–70.
11.
van der HornH.J., SpikmanJ.M., JacobsB., and van der NaaltJ. (2013). Postconcussive complaints, anxiety, and depression related to vocational outcome in minor to severe traumatic brain injury. Arch. Phys. Med. Rehabil. 94, 867–874.
12.
GouldK.R., PonsfordJ.L., and SpitzG. (2014). Association between cognitive impairments and anxiety disorders following traumatic brain injury. J. Clin. Exp. Neuropsychol. 36, 1–14.
13.
HartT., FannJ.R., ChervonevaI., JuengstS.B., RosenthalJ.A., KrellmanJ.W., DreerL.E., and KroenkeK. (2016). Prevalence, risk factors, and correlates of anxiety at 1 year after moderate to severe traumatic brain injury. Arch. Phys. Med. Rehabil. 97, 701–707.
14.
MallyaS., SutherlandJ., PongracicS., MainlandB., and OrnsteinT.J. (2015). The manifestation of anxiety disorders after traumatic brain injury: a review. J. Neurotrauma, 32, 411–421.
15.
StéfanA., and MathéJ.-F. (2016). What are the disruptive symptoms of behavioral disorders after traumatic brain injury?. A systematic review leading to recommendations for good practices. Ann. Phys. Rehabil. Med. 59, 5–17.
16.
GreerN., SayerN.A., SpoontM., TaylorB.C., AcklandP.E., MacdonaldR., McKenzieL., RosebushC., and WiltT.J. (2020). Prevalence and severity of psychiatric disorders and suicidal behavior in service members and veterans with and without traumatic brain injury: systematic review. J. Head Trauma Rehabil. 35, 1-13.
17.
YueJ.K., BurkeJ.F., UpadhyayulaP.S., WinklerE.A., DengH., RobinsonC.K., PirracchioR., SuenC.G., SharmaS., FergusonA.R., NgwenyaL.B., SteinM.B., ManleyG.T., and TaraporeP.E. (2017). Selective serotonin reuptake inhibitors for treating neurocognitive and neuropsychiatric disorders following traumatic brain injury: an evaluation of current evidence. Brain Sci. 7, 93.
18.
American Psychiatric Association. (2013). Diagnostic and Statistical Manual of Mental Disorders, 5th ed. American Psychiatric Association: Arlington, VA.
19.
American Psychiatric Association. (2000). Diagnostic and Statistical Manual of Mental Disorders, 4th ed. American Psychiatric Association: Washington, DC.
20.
BryantR.A., O'DonnellM.L., CreamerM., McFarlaneA.C., ClarkC.R., and SiloveD. (2010). The psychiatric sequelae of traumatic injury. Am. J. Psychiatry, 167, 312–320.
21.
DebS., LyonsI., KoutzoukisC., AliI., and McCarthyG. (1999). Rate of psychiatric illness 1 year after traumatic brain injury. Am. J. Psychiatry, 156, 374–378.
22.
BerthierM.L., KulisevskyJ., GironellA., and LopezO.L. (2001). Obsessive-compulsive disorder and traumatic brain injury: behavioral, cognitive, and neuroimaging findings. Neuropsychiatry Neuropsychol. Behav. Neurol. 14, 23–31.
23.
BombardierC.H., FannJ.R., TemkinN., EsselmanP.C., PelzerE., KeoughM., and DikmenS. (2006). Posttraumatic stress disorder symptoms during the first six months after traumatic brain injury. J. Neuropsychiatry Clin. Neurosci. 18, 501–508.
24.
DraperK., PonsfordJ., and SchonbergerM. (2007). Psychosocial and emotional outcomes 10 years following traumatic brain injury. J. Head Trauma Rehabil. 22, 278–287.
25.
SharmaA., SharmaA., JainA., MittalR., and GuptaI. (2015). Study of generalized anxiety disorder in traumatic brain injury. Br. J. Med. Med. Res. 10, 1–8.
26.
ZatzickD.F., RivaraF.P., JurkovichG.J., HogeC.W., WangJ., FanM.Y., RussoJ., TruszS.G., NathensA., and MackenzieE.J. (2010). Multisite investigation of traumatic brain injuries, posttraumatic stress disorder, and self-reported health and cognitive impairments. Arch. Gen. Psychiatry, 67, 1291–1300.
27.
HaagsmaJ.A., ScholtenA.C., AndriessenT.M., VosP.E., Van BeeckE.F., and PolinderS. (2015). Impact of depression and post-traumatic stress disorder on functional outcome and health-related quality of life of patients with mild traumatic brain injury. J. Neurotrauma, 32, 853–862.
28.
MalecJ.F., KetchumJ.M., HammondF.M., CorriganJ.D., Dams-O'ConnorK., HartT., NovackT., DahdahM., WhiteneckG.G., and BognerJ. (2019). Longitudinal effects of medical comorbidities on functional outcome and life satisfaction after traumatic brain injury: an individual growth curve analysis of NIDILRR traumatic brain injury model system data. J. Head Trauma Rehabil. 34, E24–E35.
29.
PonsfordJ., AlwayY., and GouldK.R. (2018). Epidemiology and natural history of psychiatric disorders after TBI. J. Neuropsychiatry Clin. Neurosci. 30, 262–270.
30.
McMillanT.M., WilliamsW.H., and BryantR. (2003). Post-traumatic stress disorder and traumatic brain injury: a review of causal mechanisms, assessment,and treatment. Neuropsychol. Rehabil. 13, 149–164.
31.
AlwayY., GouldK.R., McKayA., JohnstonL., and PonsfordJ. (2016). The evolution of post-traumatic stress disorder following moderate-to-severe traumatic brain injury. J. Neurotrauma, 33, 825–831.
32.
KennedyJ.E., JaffeeM.S., LeskinG.A., StokesJ.W., LealF.O., and FitzpatrickP.J. (2007). Posttraumatic stress disorder and posttraumatic stress disorder-like symptoms and mild traumatic brain injury. J. Rehabil. Res. Dev. 44, 895–920.
33.
BrennerL.A. (2011). Neuropsychological and neuroimaging findings in traumatic brain injury and post-traumatic stress disorder. Dialogues Clin. Neurosci. 13, 311–323.
34.
Rydon-GrangeM., and CoetzerR. (2015). What do we know about obsessive-compulsive disorder following traumatic brain injury?. CNS spectrums, 20, 463–465.
35.
CoetzerB.R. (2004). Obsessive-compulsive disorder following brain injury: a review. Int. J. Psychiatry Med. 34, 363–377.
36.
Barker-ColloS., TheadomA., JonesK., StarkeyN., KahanM., and FeiginV. (2018). Depression and anxiety across the first 4 years after mild traumatic brain injury: findings from a community-based study. Brain Inj. 32, 1651–1658.
37.
HoofienD., GilboaA., VakilE., and DonovickP.J. (2001). Traumatic brain injury (TBI) 10-20 years later: a comprehensive outcome study of psychiatric symptomatology, cognitive abilities and psychosocial functioning. Brain Inj. 15, 189–209.
38.
Senathi-RajaD., PonsfordJ., and SchonbergerM. (2010). The association of age and time postinjury with long-term emotional outcome following traumatic brain injury. J. Head Trauma Rehabil. 25, 330–338.
39.
KoponenS., TaiminenT., PortinR., HimanenL., IsoniemiH., HeinonenH., HinkkaS., and TenovuoO. (2002). Axis I and II psychiatric disorders after traumatic brain injury: a 30-year follow-up study. Am. J. Psychiatry, 159, 1315–1321.
40.
PonsfordJ., DraperK., and SchonbergerM. (2008). Functional outcome 10 years after traumatic brain injury: its relationship with demographic, injury severity, and cognitive and emotional status. J. Int. Neuropsychol. Soc. 14, 233–242.
41.
HammondF.M., CorriganJ.D., KetchumJ.M., MalecJ.F., Dams-O'ConnorK., HartT., NovackT.A., BognerJ., DahdahM.N., and WhiteneckG.G. (2019). Prevalence of medical and psychiatric comorbidities following traumatic brain injury. J. Head Trauma Rehabil. 34, E1–E10.
GouldK.R., PonsfordJ.L., JohnstonL., and SchonbergerM. (2011). Predictive and associated factors of psychiatric disorders after traumatic brain injury: a prospective study. J. Neurotrauma, 28, 1155–1163.
44.
BryantR.A., MarosszekyJ.E., CrooksJ., BaguleyI., and GurkaJ. (2000). Coping style and post-traumatic stress disorder following severe traumatic brain injury. Brain Inj. 14, 175–180.
45.
AlwayY., McKayA., PonsfordJ., and SchonbergerM. (2012). Expressed emotion and its relationship to anxiety and depression after traumatic brain injury. Neuropsychol. Rehabil. 22, 374–390.
46.
SchonbergerM., PonsfordJ., GouldK.R., and JohnstonL. (2011). The temporal relationship between depression, anxiety, and functional status after traumatic brain injury: a cross-lagged analysis. J. Int. Neuropsychol. Soc. 17, 781–787.
47.
ScheutzowM.H., and WiercisiewskiD.R. (1999). Subject review panic disorder in a patient with traumatic brain injury: a case report and discussion. Brain Inj. 13, 705–714.
48.
FannJ.R., BuringtonB., LeonettiA., JaffeK., KatonW.J., and ThompsonR.S. (2004). Psychiatric illness following traumatic brain injury in an adult healthMaintenance organization population. Arch. Gen. Psychiatry, 61, 53–61.
49.
Van PraagD.L.G., CnossenM.C., PolinderS., WilsonL., and MaasA.I.R. (2019). Post-traumatic stress disorder after civilian traumatic brain injury: a systematic review and meta-analysis of prevalence rates. J. Neurotrauma, 36, 3220–3232.
50.
KaplanG.B., Leite-MorrisK.A., WangL., RumbikaK.K., HeinrichsS.C., ZengX., WuL., ArenaD.T., and TengY.D. (2018). Pathophysiological bases of comorbidity: traumatic brain injury and post-traumatic stress disorder. J. Neurotrauma, 35, 210–225.
51.
KnutsonK.M., RakowskyS.T., SolomonJ., KruegerF., RaymontV., TierneyM.C., WassermannE.M., and GrafmanJ. (2013). Injured brain regions associated with anxiety in Vietnam veterans. Neuropsychologia, 51, 686–694.
52.
FranciscoG.E., WalkerW.C., ZaslerN.D., and BouffardM.H. (2007). Pharmacological management of neurobehavioural sequelae of traumatic brain injury: a survey of current physiatric practice. Brain Inj. 21, 1007–1014.
53.
Waldron-PerrineB., HanksR.A., and PerrineS.A. (2008). Pharmacotherapy for postacute traumatic brain injury: a literature review for guidance in psychological practice. Rehabil. Psychol. 53, 426–444.
54.
LuauteJ., PlantierD., WiartL., and Tell, L.; SOFMER group. (2016). Care management of the agitation or aggressiveness crisis in patients with TBI. Systematic review of the literature and practice recommendations. Ann. Phys. Rehabil. Med. 59, 58–67.
55.
SmithK.R.Jr., GouldingP.M., WildermanD., GoldfaderP.R., Holterman-HommesP., and WeiF. (1994). Neurobehavioral effects of phenytoin and carbamazepine in patients recovering from brain trauma: a comparative study. Arch. Neurol. 51, 653–660.
56.
Neurobehavioral Guidelines WorkingGroup, WardenD.L., GordonB., McAllisterT.W., SilverJ.M., BarthJ.T., BrunsJ., DrakeA., GentryT., JagodaA., KatzD.I., KrausJ., LabbateL.A., RyanL.M., SparlingM.B., WaltersB., WhyteJ., ZapataA., and ZitnayG. (2006). Guidelines for the pharmacologic treatment of neurobehavioral sequelae of traumatic brain injury. J. Neurotrauma, 23, 1468–1501.
57.
LevineJ.M. (2013). Common drug interactions following traumatic brain injury. J. Head Trauma Rehabil. 28, 151–154.
58.
LoE.H., SinghalA.B., TorchilinV.P., and AbbottN.J. (2001). Drug delivery to damaged brain. Brain Res. Brain Res. Rev. 38, 140–148.
59.
ChewE., and ZafonteR.D. (2009). Pharmacological management of neurobehavioral disorders following traumatic brain injury—a state-of-the-art review. J. Rehabil. Res. Dev. 46, 851–879.
WheatonP., MathiasJ.L., and VinkR. (2011). Impact of pharmacological treatments on cognitive and behavioral outcome in the postacute stages of adult traumatic brain injury: a meta-analysis. J. Clin. Psychopharmacol. 31, 745–757.
62.
TeasellR., BayleyM., MarshallS., and CullenN. (2019). The Evidence-Based Review of Moderate to Severe Acquired Brain Injury [E-reader Version]. https://erabi.ca/view-module-list-view/ (Last accessed July2019).
63.
GaoC., FuQ., ChenB., LiuZ., ZhouQ., and JiangZ. (2019). The influence of sertraline on depressive disorder after traumatic brain injury: a meta-analysis of randomized controlled studies. Am. J. Emerg. Med. 37, 1778–1783.
64.
KreitzerN., AnconaR., McCullumsmithC., KurowskiB.G., ForemanB., NgwenyaL.B., and AdeoyeO. (2019). The effect of antidepressants on depression after traumatic brain injury: a meta-analysis. J. Head Trauma Rehabil. 34, E47–E54.
65.
LiuQ., LiR., QuW., LiB., YangW., and CuiR. (2019). Pharmacological and non-pharmacological interventions of depression after traumatic brain injury: a systematic review. Eur. J. Pharmacol. 865, 172775.
66.
PeppelL., RibbersG., and Heijenbrok-KalM. (2020). Pharmacological and non-pharmacological interventions for depression after moderate to severe traumatic brain injury: a systematic review and meta-analysis. J. Neurotrauma, 37, 1587–1596.
67.
PlantierD., and Luaute, J.; SOFMER group. (2016). Drugs for behavior disorders after traumatic brain injury: systematic review and expert consensus leading to French recommendations for good practice. Ann. Phys. Rehabil. Med. 59, 42–57.
68.
DebS., and CrownshawT. (2004). Review of subject The role of pharmacotherapy in the management of behaviour disorders in traumatic brain injury patients. Brain Inj. 18, 1–31.
69.
SwaineB., BayleyM., LamontagneM.E., MarshallS., TruchonC., and KaganC. (2016). Clinical Practice Guideline For the Rehabilitation of Adults with Moderate to Severe Traumatic Brain Injury. Ontario Neurotrauma Foundation: Toronto, Ontario,Canada.
70.
MoherD., LiberatiA., TetzlaffJ., and AltmanD.G.; PRISMAGroup. (2009). Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann. Intern. Med. 151, 264–269, W264.
71.
LiberatiA., AltmanD.G., TetzlaffJ., MulrowC., GøtzscheP.C., IoannidisJ.P., ClarkeM., DevereauxP.J., KleijnenJ. and MoherD. (2009). The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. PLoS Med. 6, e1000100.
72.
BellerE.M., GlasziouP.P., AltmanD.G., HopewellS., BastianH., ChalmersI., GotzscheP.C., LassersonT., and Tovey, D.; and PRISMA for Abstracts Group. (2013). PRISMA for Abstracts: reporting systematic reviews in journal and conference abstracts. PLoS Med. 10, e1001419.
73.
ClayF., HopwoodM., PonsfordJ., JayaramM., BattyR., and PerryL. (2016). Pharmacotherapy for neurobehavioral symptoms in people with traumatic brain injury: a systematic review of non-randomized studies. PROSPERO. CRD42016045276.
74.
ZigmondA.S., and SnaithR.P. (1983). The hospital anxiety and depression scale. Acta Psychiatr. Scand. 67, 361–370.
75.
StollC.R.T., IzadiS., FowlerS., GreenP., SulsJ., and ColditzG.A. (2019). The value of a second reviewer for study selection in systematic reviews. Res. Synth. Methods, 10, 539–545.
76.
The Joanna Briggs Institute. (2014). Joanna Briggs Institute Reviewers' Manual: 2014 edition. The Joanna Briggs Institute: Adelaide, South Australia, Australia.
77.
JaffeeM.S. (2009). A randomized placebo-controlled trial of citalopram for anxiety disorders following traumatic brain injury. US Army Medical Research and Material Command: Fort Detrick,MD.
78.
HodgsonJ., McDonaldS., TateR., and GertlerP. (2012). A randomised controlled trial of a cognitive-behavioural therapy program for managing social anxiety after acquired brain injury. Brain Impairment, 6, 169–180.
79.
PonsfordJ., LeeN.K., WongD., McKayA., HainesK., AlwayY., DowningM., FurtadoC., and O'DonnellM.L. (2016). Efficacy of motivational interviewing and cognitive behavioral therapy for anxiety and depression symptoms following traumatic brain injury. Psychol. Med. 46, 1079–1090.
80.
BryantR.A., MouldsM., GuthrieR., and NixonR.D. (2003). Treating acute stress disorder following mild traumatic brain injury. Am. J. Psychiatry, 160, 585–587.
81.
VerberneD.P., SpauwenP.J., and van HeugtenC.M. (2019). Psychological interventions for treating neuropsychiatric consequences of acquired brain injury: a systematic review. Neuropsychol. Rehabil. 29, 1509–1542.
82.
ChunH.Y., NewmanR., WhiteleyW.N., DennisM., MeadG.E., and CarsonA.J. (2018). A systematic review of anxiety interventions in stroke and acquired brain injury: efficacy and trial design. J. Psychosom. Res. 104, 65–75.
83.
SooC., and TateR.L. (2007). Psychological treatment for anxiety in people with traumatic brain injury. Cochrane Database Syst Rev. (3),CD005239.
84.
WiartL., RicherE., DestaillatsJ.M., JosephP.A., DehailP., and MazauxJ.M. (2012). Psychotherapeutic follow up of out patients with traumatic brain injury: preliminary results of an individual neurosystemic approach. Ann. Phys. Rehabil. Med. 55, 375–387.
85.
ClayF.J., HicksA.J., ZamanH., PonsfordJ., BattyR., PerryL.A., and HopwoodM. (2019). Prophylaxis pharmacotherapy to prevent the onset of post-traumatic brain injury depression: a systematic review. J. Neurotrauma, 36, 2053–2064.
86.
LanctotK.L., RapoportM.J., ChanF., RajaramR.D., StraussJ., SicardT., McCullaghS., FeinsteinA., KissA., KennedyJ.L., BassettA.S., and HerrmannN. (2010). Genetic predictors of response to treatment with citalopram in depression secondary to traumatic brain injury. Brain Inj. 24, 959–969.
87.
MaasA.I., Harrison-FelixC.L., MenonD., AdelsonP.D., BalkinT., BullockR., EngelD.C., GordonW., Langlois-OrmanJ., LewH.L., RobertsonC., TemkinN., ValadkaA., VerfaellieM., WainwrightM., WrightD.W., and SchwabK. (2011). Standardizing data collection in traumatic brain injury. J. Neurotrauma, 28, 177–187.
88.
WildeE.A., WhiteneckG.G., BognerJ., BushnikT., CifuD.X., DikmenS., FrenchL., GiacinoJ.T., HartT., MalecJ.F., MillisS.R., NovackT.A., ShererM., TulskyD.S., VanderploegR.D., and von SteinbuechelN. (2010). Recommendations for the use of common outcome measures in traumatic brain injury research. Arch. Phys. Med. Rehabil. 91, 1650–1660.e17.
89.
MooreE.L., Terryberry-SpohrL., and HopeD.A. (2006). Mild traumatic brain injury and anxiety sequelae: a review of the literature. Brain Inj. 20, 117–132.
90.
RapoportM.J., ChanF., LanctotK., HerrmannN., McCullaghS., and FeinsteinA. (2008). An open-label study of citalopram for major depression following traumatic brain injury. J Psychopharmacol. 22, 860–864.
91.
PolichG., IaccarinoM.A., KaptchukT.J., Morales-QuezadaL., and ZafonteR. (2018). Placebo effects in traumatic brain injury. J. Neurotrauma, 35, 1205–1212.
92.
HammondF.M., ShererM., MalecJ.F., ZafonteR.D., WhitneyM., BellK., DikmenS., BognerJ., MysiwJ., and Pershad, R.; Amantadine Irritability Multisite Study Group. (2015). Amantadine effect on perceptions of irritability after traumatic brain injury: results of the Amantadine Irritability Multisite Study. J. Neurotrauma, 32, 1230–1238.
93.
SilverJ.M., KoumarasB., ChenM., MirskiD., PotkinS.G., ReyesP., WardenD., HarveyP.D., ArciniegasD., KatzD.I., and GunayI. (2006). Effects of rivastigmine on cognitive function in patients with traumatic brain injury. Neurology, 67, 748–755.
94.
AshmanT.A., CantorJ.B., GordonW.A., SpielmanL., FlanaganS., GinsbergA., EngmannC., EganM., AmbroseF., and GreenwaldB. (2009). A randomized controlled trial of sertraline for the treatment of depression in persons with traumatic brain injury. Arch. Phys. Med. Rehabil. 90, 733–740.
95.
FannJ.R., BombardierC.H., TemkinN., EsselmanP., WarmsC., BarberJ., and DikmenS. (2017). Sertraline for major depression during the year following traumatic brain injury: a randomized controlled trial. J. Head Trauma Rehabil. 32, 332–342.
96.
FergusonJ.M. (2001). SSRI antidepressant medications: adverse effects and tolerability. Prim. Care Companion J. Clin. Psychiatry, 3, 22–27.
97.
CastriottaR.J., WildeM.C., LaiJ.M., AtanasovS., MaselB.E., and KunaS.T. (2007). Prevalence and consequences of sleep disorders in traumatic brain injury. J. Clin. Sleep Med. 3, 349–356.
98.
MathiasJ.L., and AlvaroP.K. (2012). Prevalence of sleep disturbances, disorders, and problems following traumatic brain injury: a meta-analysis. Sleep Med. 13, 898–905.
99.
HibbardM.R., GordonW.A., FlanaganS., HaddadL., and LabinskyE. (2000). Sexual dysfunction after traumatic brain injury. NeuroRehabilitation, 15, 107–120.
100.
PonsfordJ. (2003). Sexual changes associated with traumatic brain injury. Neuropsychol. Rehabil. 13, 275–289.
101.
DowningM.G., StolwykR., and PonsfordJ.L. (2013). Sexual changes in individuals with traumatic brain injury: a control comparison. J. Head Trauma Rehabil. 28, 171–178.
102.
FaillaM.D., JuengstS.B., GrahamK.M., ArenthP.M., and WagnerA.K. (2016). Effects of depression and antidepressant use on cognitive deficits and functional cognition following severe traumatic brain injury. J. Head Trauma Rehabil. 31, E62–E73.
103.
DordingC.M., MischoulonD., PetersenT.J., KornbluhR., GordonJ., NierenbergA.A., RosenbaumJ.E., and FavaM. (2002). The pharmacologic management of SSRI-induced side effects: a survey of psychiatrists. Ann. Clin. Psychiatry, 14, 143–147.
104.
HarrowM., and JobeT.H. (2013). Does long-term treatment of schizophrenia with antipsychotic medications facilitate recovery?. Schizophr. Bull. 39, 962–965.
105.
FavaG.A. (2003). Can long-term treatment with antidepressant drugs worsen the course of depression?. J. Clin. Psychiatry, 64, 123–133.
106.
FavaG.A. (2014). Rational use of antidepressant drugs. Psychother. Psychosom. 83, 197–204.
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