Abstract
Background:
Elevated levels of free fatty acids (FFAs) play a role in the pathogenesis of insulin resistance and atherosclerosis. Adipose triglyceride lipase (also defined as patatin-like phospholipase domain containing 2 or PNPLA2) has been demonstrated to contribute to the release of FFA. The aim of this study was to investigate the association of PNPLA2 gene variations with FFA levels in healthy Chinese Han population.
Methods:
Single-nucleotide polymorphisms of PNPLA2 were genotyped using TaqMan method to perform association studies with serum level of FFA and other lipid parameters in 1765 subjects among healthy Chinese Han population. All the subjects were divided into two groups: normal FFAs group (FFAs ≤0.88 mmol/L) and high FFAs group (FFAs >0.88 mmol/L).
Results:
Neither rs7925131 nor rs7942159 was significantly associated with FFA level. We observed no difference in the genotype frequency of rs7925131 or rs7942159 between the normal FFA group and the high FFA group.
Conclusions:
Our results do not support an association of rs7925131 or rs7942159 with the FFA levels among the Chinese Han population.
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