The metabolic syndrome is a cluster of risk factor for diabetes and cardiovascular diseases. The metabolic syndrome pandemic reflects poor cardiometabolic health due to sedentary lifestyles and excess caloric intake over the background of an aging population. Sirtuins are protein deacetylases that represent master regulators of senescence, metabolism, and substrate utilization. In this perspective, we underline the pervasive role of sirtuins in the development of the typical features of metabolic syndrome and describe how sirtuins are becoming an attractive target of therapy.
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