Antimicrobial Resistance in Relation to Sero- and Genotypes Among Invasive Streptococcus pneumoniae in Finland,2007–2011

Abstract

Aim: We studied the serotypes and antimicrobial resistance of the invasive Streptococcus pneumoniae that had been isolated in Finland during 5 years. The 10-valent vaccine was introduced into the National Vaccination Programme in September 2010. Methods: We examined the antimicrobial resistance and serotype distribution of the invasive pneumococci (n=4,194) that had been isolated in Finland during 2007–2011. The penicillin-resistant (PEN R) (≥4 mg/L) isolates (n=12) were genotyped by MLST. Results: Serotype 14 was consistently the most prominent serotype, covering 18.0–20.1% of all the isolates. The proportion of serotypes 3, 19A, and 22F increased significantly, while that of 6B and the PCV10 vaccine serotypes combined decreased. PEN nonsusceptibility (≥0.12 mg/L) increased, ranging from 14.4% to 23.2% by year, and was the highest (28.5%) among the 0–2 year olds. The PEN and/or erythromycin (ERY) nonsusceptibility of several vaccine serotypes (4, 6B, 14, and 19F) increased significantly over the study period. The ERY nonsusceptibility was 26.6%. There was limited diversity among the PEN R isolates; all were a part of serotype 19F, 19A, or 14, and two globally disseminated genetic lineages carrying one or both pilus-encoding islets. Conclusions: High and/or increasing nonsusceptibility rates underline the importance of monitoring the serotype distribution and antimicrobial susceptibility of pneumococci, especially after large-scale vaccination.