Tuberculous meningitis is the most severe form of tuberculosis and causes substantial morbidity and mortality in adults and children. The prevalence of multidrug-resistant (rifampin-isoniazid) strains requires the use of more toxic second-line drugs. We report a case of tuberculous meningitis in a 3-year-old Italian child.
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References
1.
BergemannA., KarstaedtA.S.1996. The spectrum of meningitis in a population with high prevalence of HIV disease. QJM, 89:499–504.
2.
DeBarberA.E., MdluliK., BosmanM., BekkerL.G., BarryC.E.III. 2000. Ethionamide activation and sensitivity in multidrug-resistant Mycobacterium tuberculosis. Proc. Natl. Acad. Sci. U. S. A., 97:9677–9682.
3.
DonaldP.R., SirgelF.A., VenterA., ParkinD.P., SeifartH.I., van de WalB.W., MaritzJ.S., FourieP.B.2003. Early bactericidal activity of antituberculosis agents. Expert Rev. Anti. Infect Ther., 1:141–155.
4.
DoverL.G., AlahariA., GratraudP., GomesJ.M., BhowruthV., ReynoldsR.C., BesraG.S., KremerL.2007. EthA, a common activator of thiocarbamide-containing drugs acting on different mycobacterial targets. Antimicrob. Agents Chemother., 51:1055–1063.
5.
EllardG.A., HumphriesM.J., AllenB.W.1993. Cerebrospinal fluid drug concentrations and the treatment of tuberculous meningitis. Am. Rev. Respir. Dis., 148:650–655.
6.
GirgisN.I., YassinM.W., SippelJ.E., SorensenK., HassanA., MinerW.F., FaridZ., Abu el EllaA.1976. The value of ethambutol in the treatment of tuberculous meningitis. J. Trop. Med. Hyg., 79:14–17.
7.
GirgisN.I., YassinM.W., LaughlinL.W., EdmanD.C., FaridZ., WattenR.H.1978. Rifampicin in the treatment of tuberculous meningitis. J. Trop. Med. Hyg., 81:246–247.
8.
HausteinT., RidoutD.A., HartleyJ.C., ThakerU., ShingadiaD., KleinN.J., NovelliV., DixonG.L.2009. The likelihood of an indeterminate test result from a whole-blood interferon-gamma release assay for the diagnosis of mycobacterium tubecrculosis infection in children correlates with age and immune status. Pediatr. Infect. Dis. J., 28:669–673.
OzatesM., KemalogluS., GurkanF., OzkanU., HoşogluS., SimşekM.M.2000. CT of the brain in tuberculous meningitis. A review of 289 patients. Acta Radiol., 41:13–17.
11.
PhuapraditP., SupmonchaiK., KaojarernS., MokkhavesaC.1990. The blood/cerebrospinal fluid partitioning of pyrazinamide: a study during the course of treatment of tuberculous meningitis. J. Neurol. Neurosurg. Psychiatry, 53:81–82.
12.
SilberE., SonnenbergP., HoK.C., KoornhofH.J., EintrachtS., MorrisL., SafferD.1999. Meningitis in a community with a high prevalence of tuberculosis and HIV infection. J. Neurol. Sci., 162:20–26.
13.
World Health Organization. 2008. Guidelines for the Programmatic Management of Drug-resistant Tuberculosis: Emergency Update 2008. World Health Organization, Stop TB Department: Geneva.
14.
World Health Organization. 2009. Global Tuberculosis Control–Epidemiology, Strategy, Financing. WHO/HTN/TB/2009.411. WHO: Geneva, Switzerland.
