Antibodies are the Forefront of Today's Medicine

Mullard A : FDA approves 100th monoclonal antibody product. Nat Rev Drug Discov. 2021; 5:021-00079.

Patel A , Bah MA , Weiner DB : In Vivo Delivery of Nucleic Acid-Encoded Monoclonal Antibodies. BioDrugs. 2020; 34:273–293. doi: 210.1007/s40259-40020-00412-40253.

Steplewski Z , Thurin M , Kieber-Emmons T : Antibodies: At The Nexus of Antigens and Cancer Vaccines. J Infect Dis. 2015; 212 Suppl 1:S59–66. doi: 10.1093/infdis/jiu1638.

Sears HF , Atkinson B , Mattis J , Ernst C , Herlyn D , Steplewski Z , Häyry P , Koprowski H : Phase-I clinical trial of monoclonal antibody in treatment of gastrointestinal tumours. Lancet. 1982; 1:762–765. doi: 710.1016/s0140-6736(1082)91811-91816.

Herlyn D , Wettendorff M , Schmoll E , Iliopoulos D , Schedel I , Dreikhausen U , Raab R , Ross AH , Jaksche H , Scriba M , et al.: Anti-idiotype immunization of cancer patients: modulation of the immune response. Proc Natl Acad Sci U S A. 1987; 84:8055–8059. doi: 8010.1073/pnas.8084.8022.8055.

Koprowski H , Steplewski Z , Herlyn D , Herlyn M : Study of antibodies against human melanoma produced by somatic cell hybrids. Proc Natl Acad Sci U S A. 1978; 75:3405–3409. doi: 3410.1073/pnas.3475.3407.3405.

Koprowski H , Herlyn D , Lubeck M , DeFreitas E , Sears HF : Human anti-idiotype antibodies in cancer patients: Is the modulation of the immune response beneficial for the patient?. Proc Natl Acad Sci U S A. 1984; 81:216–219. doi: 210.1073/pnas.1081.1071.1216.

Bechtel B , Wand AJ , Wroblewski K , Koprowski H , Thurin J : Conformational analysis of the tumor-associated carbohydrate antigen 19-9 and its Lea blood group antigen component as related to the specificity of monoclonal antibody CO19-9. J Biol Chem. 1990; 265:2028–2037.

Blaszczyk-Thurin M , Murali R , Westerink MA , Steplewski Z , Co MS , Kieber-Emmons T : Molecular recognition of the Lewis Y antigen by monoclonal antibodies. Protein Eng. 1996; 9:447–459. doi: 410.1093/protein/1099.1095.1447.

Pichla SL , Murali R , Burnett RM : The crystal structure of a Fab fragment to the melanoma-associated GD2 ganglioside. J Struct Biol. 1997; 119:6–16. doi: 10.1006/jsbi.1997.3857.

Sun J , Thurin J , Cooper HS , Wang P , Mackiewicz M , Steplewski Z , Blaszczyk-Thurin M : Elevated expression of H type GDP-L-fucose:beta-D-galactoside alpha-2-L-fucosyltransferase is associated with human colon adenocarcinoma progression. Proc Natl Acad Sci U S A. 1995; 92:5724–5728. doi: 5710.1073/pnas.5792.5712.5724.

Herlyn M , Steplewski Z , Herlyn D , Koprowski H : Colorectal carcinoma-specific antigen: detection by means of monoclonal antibodies. Proc Natl Acad Sci U S A. 1979; 76:1438–1442. doi: 1410.1073/pnas.1476.1433.1438.

Iliopoulos D , Ernst C , Steplewski Z , Jambrosic JA , Rodeck U , Herlyn M , Clark WH Jr ., Koprowski H , Herlyn D : Inhibition of metastases of a human melanoma xenograft by monoclonal antibody to the GD2/GD3 gangliosides. J Natl Cancer Inst. 1989; 81:440–444. doi: 410.1093/jnci/1081.1096.1440.