Abstract
Background:
Pure laparoscopic liver donor right hepatectomy (LLDRH) remains challenging, and its value is still unclear compared with open liver donor right hepatectomy (OLDRH).
Objective:
To provide comprehensive evidence about the safety and efficacy of LLDRH.
Methods:
The MEDLINE, Embase, Web of Science, and Cochrane Library electronic databases were searched from the date of inception to July 2021. A fixed-effects or random-effects model was used to analyze the pooled data by using Review Manager Version 5.3.
Results:
A total of 1940 patients from 6 studies were enrolled in this meta-analysis. For perioperative outcomes of donors, LLDRH had a longer operative time than OLDRH (weighted mean difference [WMD] = 29.75 [4.23–55.26] minutes, P = .02), but it had lower overall morbidity (odds ratio [OR] = 0.67 [0.45–0.99], P = .04), fewer pulmonary complications (OR = 0.47 [0.29–0.76], P = .002), and shorter hospital stays (WMD = −1, P < .001) than OLDRH. However, major complications, biliary complications, portal vein problems, and intra-abdominal bleeding were comparable between the 2 groups. With regard to the postoperative data of recipients, the risks of biliary problems, hepatic artery problems, portal vein problems, hepatic vein problems, and postoperative liver failure were similar between the 2 groups.
Conclusions:
LLDRH for living donors is safe and effective, and it offers superior perioperative outcomes to OLDRH.
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Supplementary Material
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