Background: The influence of laparoscopic cholecystectomy on coagulation and fibrinolysis is debatable.
There have been a few but controversial studies and the need for routine antithrombotic
prophylaxis is unclear.
Materials and Methods: In this prospective study we investigated changes in coagulation and fibrinolysis
parameters in laparoscopic cholecystectomy. Blood samples taken before, during, and after
surgery from 38 consecutive patients were analyzed. Measured parameters included the international
normalized ratio, prothrombin time, partial thromboplastin time, antithrombin III activity,
platelet count, mean platelet volume, fibrinogen, and D-dimers.
Results: Statistically significant changes included increased perioperative international normalized
ratio and D-dimers, and postoperative antithrombin III, fibrinogen, and D-dimers, as well as
decreased perioperative antithrombin III and fibrinogen and postoperative international normalized
ratio, platelet count, and mean platelet volume. Values of partial thromboplastin time had no
statistically significant changes.
Conclusion: Reduced coagulation activity and increased fibrinolytic activity occur during and after
laparoscopic cholecystectomy.
