Abstract
Background:
Mouthpiece ventilation (MPV) reduces hypoventilation, but its efficacy in relieving dyspnea in patients with acute chronic obstructive pulmonary disease exacerbation (AECOPD) is unclear.
Objective:
To assess the feasibility of MPV in relieving dyspnea among patients with AECOPD.
Methods:
In this prospective single-arm pilot study, the change in dyspnea on numeric rating scale (NRS) after using MPV and side effects of the treatment were studied in 18 patients with AECOPD.
Results:
The median decrease in dyspnea was 1.5 (95% confidence interval = 0.0–2.5, p = 0.006) on NRS after the intervention lasting a median of 16.9 minutes. Of the patients, 61% found MPV beneficial. The use of MPV did not increase the sense of anxiety or pain.
Conclusions:
MPV is feasible and may relieve dyspnea in patients with AECOPD, but the intervention needs further evaluation.
clinicaltrials.gov study number: NCT03025425
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