Deprescribing Cholinesterase Inhibitors at the End of Life #354

American Psychiatric Association. Practice Guideline for the Treatment of Patients with Alzheimer's Disease and Other Dementias. 2nd ed. Arlington, VA: American Psychiatric Association, 2007.

Duthey B . Alzheimer's disease and other dementias. A Public Health Approach to Innovation. 2013. http://who.int/medicines/areas/priority-medicinesBP6-11Alzheimer.pdf (last accessed February 7, 2018).

Lane RM , Potkin SG , Enz A . Targeting acetylcholinesterase and butyrylcholinesterase in dementia. Int J Neuropsychopharmacol, 2006; 9:101–124.

Gauthier S , Patterson C , Chertkow H , et al.: Recommendations of the 4th Canadian Consensus Conference on the Diagnosis and Treatment of Dementia (CCCDTD4). Can Geriatr J, 2012; 15:120–126.

Rising Tide: The Impact of Dementia on Canadian Society. Alzheimer Society of Canada; 2010.

Rolinski M , Fox C , Maidment I , McShane R : Choleniesterase inhibitors for dementia with Lewy bodies, Parkinson's disease. Cochrane Database of Syst Revi, 2012; 3:CD006504.

Trinh NH , Hoblyn J , Mohanty S , Yaffe K . Efficacy of cholinesterase inhibitors in the treatment of neuropsychiatric symptoms and functional impairment in Alzheimer disease: A meta-analysis. JAMA, 2003; 289:210–216.

Hogan DB , Bailey P , Black S , et al. Diagnosis and treatment of dementia: 5. Nonpharmacologic and pharmacologic therapy for mild to moderate dementia. CMAJ, 2008; 179:1019–1026.

Birks J . Cholinesterase inhibitors for Alzheimer's disease. Cochrane Database Syst Rev, 2006; 25:CD005593.

Herrmann N , O'Regan J , Ruthirakuhan M , et al. A randomized placebo-controlled discontinuation study of cholinesterase inhibitors in institutionalized patients with moderate to severe Alzheimer disease. J Am Med Dir Assoc, 2016; 17:142–147.

Lee J , Monette J , Sourial N , et al. The use of a cholinesterase inhibitor review committee in long-term care. J Am Med Dir Assoc, 2007; 8:243–247.

Bidzan L , Bidzan M . Withdrawal syndrome after donepezil cessation in a patient with dementia. Neurol Sci, 2012; 33:1459–1461.

Singh S , Dudley C . Discontinuation syndrome following donepezil cessation. Int J Geriatr Psychiatry, 2003; 18:282–284.

Grassi L , Caraceni A , Mitchell AJ , et al. Management of delirium in palliative care: A review. Curr Psychiatry Rep, 2015; 17:550.

Sadowsky CH , Dengiz A , Olin JT , et al. Switching from donepezil tablets to rivastigmine transdermal patch in Alzheimer's disease. Am J Alzheimers Dis Other Demen, 2009; 24:267–275.