Photodynamic Therapy for Conjunctival Ocular Surface Squamous Neoplasia

Abstract

Abstract

Purpose:

To report the case about a patient with conjunctival ocular surface squamous neoplasia who responded well to ocular photodynamic therapy (PDT).

Case:

A 75-year-old man underwent PDT for his biopsy-proven conjunctival squamous cell dysplasia that was extending onto the cornea. Patient received 2 treatments of PDT with verteporfin (6 mg/m² body surface area, intravenously) with 2 months apart. The light dose was calculated as 50 J/cm². Whole lesion was irradiated 1 min after injection.

Results:

Half of the mass regressed after first PDT. Second PDT resulted in near-complete cure of remaining lesion within 2 weeks. The patient remained stable for the 13 months.

Conclusion:

PDT may be useful in some cases of extensive ocular surface squamous neoplasia that is less than invasive.