Objective: The aim of this study was to compare the visual acuity change after an intravitreal
high-dose injection of triamcinolone acetonide (TA) in various types of exudative agerelated
macular degeneration (AMD).
Participants: The interventional comparative case series study included 142 patients (146
eyes) with progressive exudative AMD differentiated into the occult type (n = 78; 53.4%), minimal
classic type (n = 45; 30.8%), predominantly classic type (n = 17; 11.6%), and the purely
classic type (n = 6; 4.1%). Mean follow-up was 9.7 ± 7.0 months (3–35.7 months).
Methods: Single intravitreal injection of approximately 20 mg of TA.
Outcome measures: Visual acuity, intraocular pressure (IOP).
Results: Gain in visual acuity measured at 1 month (P = 0.20), 2 months (P = 0.43), and at
3 months (P = 0.38) after the intravitreal injection of triamcinolone and maximal gain in visual
acuity during the whole follow-up (P = 0.81) did not vary significantly between the 4
study groups. Correspondingly, the size of a retinal pigment epithelium detachment was not
significantly associated with the change in visual acuity at 1 month (P = 0.62), 2 months (P =
0.24), 3 months (P = 0.96), or the maximal gain in visual acuity during follow-up (P = 0.93).
The amount of rise in IOP, compared with the baseline value (6.5 ± 7.4 mmHg), was statistically
not associated with the type of subfoveal membrane (P = 0.20; 95% confidence interval:
–0.52, 2.45).
Conclusions: The change in visual acuity and the rise in IOP in patients with exudative
AMD receiving an intravitreal triamcinolone monotherapy is statistically independent of the
type of subfoveal membrane, including the size of a retinal epithelium detachment.
