Purpose: The aim of this study was to report on the possible development of corneal endothelial
deposits resulting from the use of rifabutin.
Methods: Case series consisting of 3 patients treated with rifabutin were retrospectively
studied. Two of the patients were infected with human immunodeficiency virus. A corneal
and external disease specialist performed a complete ophthalmologic exam and obtained medical
histories of the patients.
Results: All cases developed corneal endothelial deposits after previous use of rifabutin.
The deposits were bilateral, yellow-white colored, stellate, and mainly peripheral.
Conclusions: In these 3 cases, the unique positive ocular finding was corneal endothelial
deposits, which may be related to the use of rifabutin.
