Abstract
ABSTRACT
The kinetics of topically applied norfloxacin 0.3 percent were studied in rabbit and man. All measurements were performed by high-pressure liquid chromatography. Norfloxacin concentrations were investigated five to 120 minutes in rabbit ocular tissues after instillation of a single drop. In normal eyes, after 30 minutes, mean ± SEM levels were 14.3 ± 3.7 μg/g in cornea, 3.3 ± 0.7 μg/g in conjunctiva, 0.2 ± 0.1 μg/g in aqueous humor. After removal of the corneal epithelium concentrations were as follows: 84.2 ± 15.8 μg/g, 7.3 ± 2.3 μg/g, 8.6 ± 1.9 μg/g respectively. Penetration in posterior ocular tissues were rather poor. In human eyes, the intracorneal concentrations were assessed in patients being operated on corneal grafts. After instillation of 5 drops, the concentration in cornea was 15.5 ± 2.1 μg/g. These data show that therapeutic levels of norfloxacin can be achieved in anterior ocular tissues, which may be of help in superficial infections of the eye.
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