Abstract
ABSTRACT
We studied the effects of a single retrobulbar injection of Botulinum toxin on the motility of cat eyes. Four cats were sedated and the opposite eye served as a control. Eye movements were plotted by reflecting a laser beam from a mirror fixed to the cornea. We found the mean degrees of deviation per eye per day and summarized these results as mean degrees of deviation per eye per week ± standard deviation. Statistical analysis was accomplished using Student's t test for independent measures, since measurement of the treated eye pairs was done in a randomized manner on different test days.
Control Week 1 (n=4) 30.74 ± 19.5 Week 2 (n=4) 16.45 ± 9.64 Week 3 (n=4) 26.48 ± 12.8 Week 4 (n=4) 25.34 ± 8.53
Treated 3.46 ± 1.77 (p< 0.01) 4.53 ± 3.74 (p< 0.01) 4.98 ± 1.94 (p< 0.001) 7.30 ± 6.01 (p< 0.001)
These results indicate that a single retrobulbar dose of Botulinum toxin can produce a paralysis of the ocular musculature lasting in excess of four weeks in a specific and reproducible manner. In addition, this methodology should prove useful in future experiments in which ocular motility might prove to be a technical concern.
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