Abstract
ABSTRACT
One hundred and seventy-eight patients undergoing uncomplicated cataract extraction with posterior chamber intraocular lens insertion completed a prospective, randomized, controlled trial of oral piroxicam in the prophylaxis of postoperative cystoid macular edema (CME), with a 1-year follow up. The incidence of: "visually significant" CME, the mean interval to onset following surgery, clinical severity, recurrence rate, and the time to achieve best corrected visual result were unaffected by a 17-day piroxicam course. Oral steroid CME treatment produced a rapid response, but could not be shown to change the ultimate visual results. High-performance liquid chromatography analysis of aqueous humor obtained at cataract surgery suggested that piroxicam's pharmacokinetics might be a factor in this lack of response; the large number of potential inflammatory mediators uninfluenced by cyclo-oxygenase inhibition also may implicate piroxicam pharmacodynamics.
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