Abstract
ABSTRACT
The Emory mouse develops a late-onset hereditary cataract bearing some resemblances to human sejope cataract. It was used as a model system for testing the effects of several drugs expected to have anticataractogenic potential. A low level of added dietary α-tocopherol had only a marginal effect. Penicillamine increased lens soluble protein, a good index of lens viability. Triethylenetetramine was too toxic to permit satisfactory treatment. Mercaptopropionylglycine produced several positive effects including a retardation of cataract at 6 months of age; parameters which increased under drug treatment were lens weight, soluble protein content and protein sulfhydryl, but not glutathione. There was no effect on the total calcium concentration.
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