Edible staghorn sumac (Rhus hirta) fruit extract was applied in conjunction with chemotherapeutic drug 5-fluorouracil to promote cytotoxicity of the drugs toward human breast cancer cells MCF-7 while protecting normal cells MCF-10A from drug toxicity. Sumac extract would be a promising chemotherapeutic drug conjugate in cancer chemotherapy.
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References
1.
ChirinoYI, Hernandez-PandoR, Pedraza-ChaveriJ: Peroxynitrite decomposition catalyst ameliorates renal damage and protein nitration in cisplatin-induced nephrotoxicity in rats. BMC Pharm, 2004; 4:20–29.
2.
AlisiA, BalsanoC: Enhancing the efficacy of hepatocellular carcinoma chemotherapeutics with natural anticancer agents. Nutr Rev, 2007; 65:550–553.
3.
NorwoodAA, TucciM, BenghuzziH: A comparison of 5-fluorouracil and natural chemotherapeutic agents, EGCG and thymoquinone, delivered by sustained drug delivery on colon cancer cells. Biomed Sci Instrum, 2007; 43:272–277.
4.
LeeCK, ParkKK, LimSS, ParkJHY, ChungWY: Effect of licorice extract against tumor growth and cisplatin induced toxicity in a mouse xenograft model of colon cancer. Biol Pharm Bull, 2007; 30:2191–2195.
5.
RobyCA, AndersonGD, KantorE, DryerDA, BursteinAH: St John's wort: effect on CYP3A4 activity. Clin Pharmacol Ther, 2000; 67:451–457.
6.
WuT, McCallumJL, WangS, LiuR, ZhuH, TsaoR: Evaluation of antioxidant activities and chemical characterisation of staghorn sumac fruit (Rhus hirta L.). Food Chem, 2013; 138:1333–1340.
7.
McCuneLM, JohnsT: Antioxidant activity in medicinal plants associated with the symptoms of diabetes mellitus used by the indigenous peoples of the North American boreal forest. J Ethnopharmacol, 2002; 82:197–205.
8.
WangS, ZhuF, MarconeMF: Synergistic interaction of sumac and raspberry mixtures in their antioxidant capacities and selective cytotoxicity against cancerous cells. J Med Food, 2014 [Epub ahead of print]; DOI: 10.1089/jmf.2013.0171.
9.
ShahMY, PanX, FixLN, FarwellMA, ZhangB: 5-Fluorouracil drug alters the microRNA expression profiles in MCF-7. J Cell Physiol, 2011; 226:1868–1878.
10.
WangS, MecklingKA, MarconeFM, KakudaY, TsaoR: Synergistic, additive and antagonistic effects of food mixtures on total antioxidant capacities. J Agric Food Chem, 2011; 59:960–968.
11.
AtkinsonTG, Meckling-GillKA: Regulation of nucleoside drug toxicity by transport inhibitors and omega-3 polyunsaturated fatty acids in normal and transformed rat-2 fibroblasts. Cell Pharm, 1995; 2:259–264.
12.
SarkarFH, LiY: Using chemopreventive agents to enhance the efficacy of cancer therapy. Cancer Res, 2006; 66:3347–3350.
13.
WangS, MecklingKA, MarconeFM, KakudaY, ProulxA, TsaoR: In vitro antioxidant synergism and antagonism between food extracts can lead to similar activities in H2O2-induced cell death, caspase-3 and MMP-2 activities in H9c2 cells. J Sci Food Agric, 2012; 92:2983–2993.
14.
WangS, ZhuF, MecklingKA, MarconeFM: Antioxidant capacity of food mixtures is not correlated with their antiproliferative activity against MCF-7 breast cancer cells. J Med food, 2013; 16:1138–1145.
15.
CampbellTC, JacobsonH: Whole: Rethinking the Science of Nutrition. BenBella Books, Inc., Dallas, TX, 2013.
16.
TanakaT, ZhangH, JiangZH: Relationship between hydrophobicity and structure of hydrolyzable tannins with crude drug constituents in aqueous solution. Chem Pharm Bull, 1997; 45:1891–1897.
17.
TanakaT, KataokaM, TsuboiN, KounoI: New monoterpene glycoside esters and phenolic constituents of Paeoniae Radix, and increase of water solubility of proanthocyanidins in the presence of paeoniflorin. Chem Pharm Bull, 2000; 48:201–207.
