Restricted accessResearch articleFirst published online 2013-03
Comparison of the Inhibitory Effect Against Copper Ion–Induced Oxidation in Rat Plasma After Oral Administration of Salvianolic Acid B and Its Decocted Solutions
The effects of salvianolic acid B (Sal B) decoction on antioxidative activities were evaluated. The 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical–scavenging activity, Fe2+-chelating activity, reducing power, and total phenolic content of the Sal B–decocted solutions did not change significantly after decoction in an aqueous solution. However, the formation of cholesteryl ester hydroperoxide (CE-OOH) in rat blood plasma containing the Sal B–decocted solutions was more effectively inhibited than that of plasma containing the Sal B solution, regardless of the decoction time. In addition, the accumulation of CE-OOH in rat plasma after oral administration of the Sal B–decocted solutions was more effectively suppressed than when the Sal B solution was administered, considering the lag time. It is likely that the decoction was partly responsible for the increased antioxidant activity in blood plasma. Therefore, the Sal B–decocted solution may contribute more to antioxidant defense in blood than a Sal B solution that is not decocted.
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