Howard A. Young's 4 Decades in Science: More Than Just Experiments

Bae HR , Hodge DL , Yang GX , et al. The interplay of type I and type II interferons in murine autoimmune cholangitis as a basis for sex-biased autoimmunity. Hepatology 2018; 67(4):1408–1419; DOI: 10.1002/hep.29524.

Bae HR , Leung PSC , Hodge DL , et al. Multi-omics: Differential expression of IFN-gamma results in distinctive mechanistic features linking chronic inflammation, gut dysbiosis, and autoimmune diseases. J Autoimmun 2020; 111:102436; DOI: 10.1016/j.jaut.2020.102436.

Bae HR , Leung PS , Tsuneyama K , et al. Chronic expression of interferon-gamma leads to murine autoimmune cholangitis with a female predominance. Hepatology 2016; 64(4):1189–1201; DOI: 10.1002/hep.28641.

Biron CA , Tarrio ML . Immunoregulatory cytokine networks: 60 years of learning from murine cytomegalovirus. Med Microbiol Immunol 2015; 204(3):345–354; DOI: 10.1007/s00430-015-0412-3.

Chen W , Jin W , Hardegen N , et al. Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med 2003; 198(12):1875–1886; DOI: 10.1084/jem.20030152.

Darnell JE Jr. Interferon research: Impact on understanding transcriptional control. Curr Top Microbiol Immunol 2007; 316:155–163; DOI: 10.1007/978-3-540-71329-6_8.

Dobrovolskaia MA , Vogel SN . 2002. Toll receptors, CD14, and macrophage activation and deactivation by LPS. Microbes Infect, 2002;4(9):903–914; DOI: 10.1016/s1286-s4579(02)01613-1.

Ellis RW , Defeo D , Shih TY , et al. The p21 src genes of Harvey and Kirsten sarcoma viruses originate from divergent members of a family of normal vertebrate genes. Nature 1981; 292(5823):506–511; DOI: 10.1038/292506a0.

Greenwell-Wild T , Vazquez N , Jin W , et al. Interleukin-27 inhibition of HIV-1 involves an intermediate induction of type I interferon. Blood 2009; 114(9):1864–1874; DOI: https://doi.org/10.1182/blood-2009-03-211540.

Hisert KB , Kirksey MA , Gomez JE , et al. Identification of Mycobacterium tuberculosis counterimmune (cim) mutants in immunodeficient mice by differential screening. Infect Immun 2004; 72(9):5315–5321; DOI: 10.1128/IAI.72.9.5315-5321.2004.

Hodge DL , Berthet C , Coppola V , et al. IFN-gamma AU-rich element removal promotes chronic IFN-gamma expression and autoimmunity in mice. J Autoimmun 2014; 53:33–45; DOI: 10.1016/j.jaut.2014.02.003.

Hodge DL , Martinez A , Julias JG , et al. Regulation of nuclear gamma interferon gene expression by interleukin 12 (IL-12) and IL-2 represents a novel form of posttranscriptional control. Mol Cell Biol 2002; 22(6):1742–1753; DOI: 10.1128/MCB.22.6.1742-1753.2002.

Ivashkiv LB. IFNgamma: Signalling, epigenetics and roles in immunity, metabolism, disease and cancer immunotherapy. Nat Rev Immunol 2018; 18(9):545–558; DOI: 10.1038/s41577-018-0029-z.

Lyakh LA , Sanford M , Chekol S , et al. TGF-beta and vitamin D3 utilize distinct pathways to suppress IL-12 production and modulate rapid differentiation of human monocytes into CD83+ dendritic cells. J Immunol 2005; 174(4):2061–2070; DOI: 10.4049/jimmunol.174.4.2061.

Mangan PR , Harrington LE , O'Quinn DB , et al. Transforming growth factor-beta induces development of the T(H)17 lineage. Nature 2006; 441(7090):231–234; DOI: 10.1038/nature04754.

Martinez FO , Gordon S. The evolution of our understanding of macrophages and translation of findings toward the clinic. Expert Rev Clin Immunol 2015; 11(1):5–13; DOI: 10.1586/1744666X.2015.985658.

McCartney-Francis NL , Wahl SM . Dysregulation of IFN-gamma signaling pathways in the absence of TGF-beta 1. J Immunol 2002; 169(10):5941–5947; DOI: 10.4049/jimmunol.169.10.5941.

Orenstein JM , Fox C , Wahl SM . Macrophages as a source of HIV during opportunistic infections. Science 1997; 276(5320):1857–1861; DOI: 10.1126/science.276.5320.1857.

Peng G , Lei KJ , Jin W , et al. Induction of APOBEC3 family proteins, a defensive maneuver underlying interferon-induced anti-HIV-1 activity. J Exp Med 2006; 203(1):41–46; DOI: 10.1084/jem.20051512.

Sica A , Dorman L , Viggiano V , et al. Interaction of NF-kappaB and NFAT with the interferon-gamma promoter. J Biol Chem 1997;272 (48):30412–30420. https://doi.org/10.1074/jbc.272.48.30412.

Sica A , Tan TH , Rice N , et al. The c-rel protooncogene product c-Rel but not NF-kappa B binds to the intronic region of the human interferon-gamma gene at a site related to an interferon-stimulable response element. Proc Natl Acad Sci U S A 1992; 89(5):1740–1744; https://doi.org/10.1073/pnas.89.5.1740.

Stark GR , Darnell JE Jr . The JAK-STAT pathway at twenty. Immunity 2012; 36(4):503–514; DOI: 10.1016/j.immuni.2012.03.013.

Trinchieri G , Sher A. Cooperation of Toll-like receptor signals in innate immune defence. Nat Rev Immunol 2007; 7(3):179–190; DOI: 10.1038/nri2038.

Valencia JC , Erwin-Cohen RA , Clavijo PE , et al. Myeloid-derived suppressive cell expansion promotes melanoma growth and autoimmunity by inhibiting CD40/IL27 regulation in macrophages. Cancer Res 2021; 81(23):5977–5990; DOI: 10.1158/0008-5472.CAN-21-1148.

Varmus HE , Ringold G , Yamamoto KR . Regulation of mouse mammary tumor virus gene expression by glucocorticoid hormones. Monogr Endocrinol 1979; 12:253–278; DOI: 10.1007/978-3-642-81265-1_14.

Vazquez N , Greenwell-Wild T , Rekka S , et al. Mycobacterium avium-induced SOCS contributes to resistance to IFN-gamma-mediated mycobactericidal activity in human macrophages. J Leukoc Biol 2006; 80(5):1136–1144; DOI: 10.1189/jlb.0306206.

Vazquez N , Schmeisser H , Dolan MA , et al. Structural variants of IFNalpha preferentially promote antiviral functions. Blood 2011; 118(9):2567–2577; DOI: 10.1182/blood-2010-12-325027.

Wahl SM. Transforming growth factor beta: the good, the bad, and the ugly. J Exp Med 1994; 180(5):1587–1590. https://doi.org/10.1084/jem.180.5.1587.

Wahl SM , Hunt DA , Wakefield LM , et al. Transforming growth factor type beta induces monocyte chemotaxis and growth factor production. Proc Natl Acad Sci U S A 1987; 84(16):5788–5792. https://doi.org/10.1073/pnas.84.16.5788.

Young HA , Bream JH . IFN-gamma: recent advances in understanding regulation of expression, biological functions, and clinical applications. Curr Top Microbiol Immunol 2007; 316:97–117. https://doi.org/10.1007/978-3-540-71329-6_6.

Young HA , Ghosh P , Ye J , et al. Differentiation of the T helper phenotypes by analysis of the methylation state of the IFN-gamma gene. J Immunol 1994; 153(8):3603–3610. https://www.ncbi.nlm.nih.gov/pubmed/7523497.

Young HA , Scolnick EM , Parks WP . Glucocorticoid-receptor interaction and induction of murine mammary tumor virus. J Biol Chem 1975; 250(9):3337–3343. https://www.ncbi.nlm.nih.gov/pubmed/164467.

Young HA , Shih TY , Scolnick EM , et al. Steroid induction of mouse mammary tumor virus: effect upon synthesis and degradation of viral RNA. J Virol 1977; 21(1):139–146. https://doi.org/10.1128/JVI.21.1.139-146.1977.