We describe a rare case of a 58-year-old female with ocular surface squamous neoplasia (OSSN) in her left eye. She was treated for 12 months with topical interferon alpha-2b (IFNα-2b) eye drops and OSSN resolved completely. She presented with a whitish elevated lesion involving the cornea, limbus, and conjunctival surface after discontinuation of topical IFNα-2b. Excision biopsy along with amniotic membrane grafting was done to stabilize the ocular surface. Histopathological evaluation of the excised tissue revealed ocular surface inflammation with no evidence of malignancy.
Get full access to this article
View all access options for this article.
References
1.
ButlerNJ, SuhlerEB, RosenbaumJT. 2012. Interferon alpha 2b in the treatment of uveitic cystoid macular edema. Ocul Immunol Inflamm, 20(2):86–90.
2.
LewczukN, ZdebikA, BogusławskaJ. 2019. Interferon alpha 2a and 2b in ophthalmology: a review. J Interferon Cytokine Res, 39(5):259–272.
3.
MalekiA, AghaeiH, LeeS. 2018. Topical interferon alpha 2b in the treatment of refractory pseudophakic cystoid macular edema. Am J Ophthalmol Case Rep, 10:203–205.
