Recently, the relationship between functional interleukin-6 (IL-6) polymorphisms and coronary artery disease (CAD) was extensively studied, with controversial findings. Therefore, we conducted this meta-analysis to better elucidate the relationship between these polymorphisms and the risk of CAD. A total of 57 case–control studies were finally included. The overall analyses showed that IL-6 −174G>C and −572G>C polymorphisms were significantly associated with the risk of CAD, the C allele of −174G>C (G versus C, odds ratio [OR] = 0.82, confidence interval [95% CI] = 0.75–0.89) and −572G>C polymorphisms (G versus C, OR = 0.82, 95% CI = 0.74–0.92) conferred an increased susceptibility to CAD. Further subgroup analyses yielded similar positive results for −174G>C polymorphism in Asian and Caucasian populations, and for −572G>C polymorphism in Asian and African populations. In conclusion, our findings suggest that IL-6 −174G>C and −572G>C polymorphisms may serve as potential genetic markers of CAD.
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