The fibroblast growth factor (FGF) signaling pathway is integral to the pathogenesis of many airway diseases and in the growth and development of the normal lung. The FGF pathway has a role in key regulatory pathways of fibrosis, and provides a number of potential therapeutic targets for future research.
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References
1.
AmbalavananN, NovakZ. 2003. Peptide growth factors in tracheal aspirates of mechanically ventilated preterm neonates. Pediatr Res, 53:240–244.
2.
BlackPN, YoungPG, SkinnerSJ. 1996. Response of airway smooth muscle cells to TGF-beta 1: effects on growth and synthesis of glycosaminoglycans. Am J Physiol, 271:L910–L917.
ChenG, KhalilN. 2006. TGF-beta 1 increases proliferation of airway smooth muscle cells by phosphorylation of map kinases. Respir Res, 7:2.
5.
CohenP, RajaR, RosenbloomJ, HerrickDJ. 2000. IGFBP-1 mediates TGF-beta 1-induced cell growth in human airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol, 278:L545–L551.
6.
DosanjhA, RednamS, MartinM. 2003. Respiratory syncytial virus augments production of fibroblast growth factor basic in vitro: implications for a possible mechanism of prolonged wheezing after infection. Pediatr Allergy Immunol, 14:437–440.
7.
ElluruR, ThompsonF, ReeceA. 2009. Fibroblast growth factor 18 gives growth and directional cues to airway cartilage. Laryngoscope, 119:1153–1165.
8.
HokutoI, PerlA, WhittsettJ. 2004. FGF signaling is required for pulmonary homeostasis following hyperoxia. Am J Physiol Lung Cell Mol Physiol, 286:L580–L587.
9.
Lappi-BlancoE, SoiniY, KinnulaV, PaakkoP. 2002. VEGF and bFGF are highly expressed in intraluminal fibromyxoid lesions in bronchiolitis obliterans organizing pneumonia. J Pathol, 196:220–227.
10.
MartinezFD. 2000. Viruses and atopic sensitization in the first years of life. Am J Respir Crit Care Med, 162:S95–S99.
McMillanSJ, XanthouG, LloydCM. 2005. Manipulation of allergen-induced airway remodeling by treatment with anti-TGF-beta antibody: effect on the SMAD signaling pathway. J Immunol, 174:5774–5780.
13.
MorrisDG, HuangX, KaminskiNet al.2003. Loss of integrin alpha(v)beta6-mediated TGF-beta activation causes Mmp12-dependent emphysema. Nature, 422:169–173.
14.
PierceGF, TarpleyJE, YanagiharaD, MustoeTAet al.1992. Platelet-derived growth factor, transforming growth factor b1 and basic fibroblast growth factor in dermal wound healing. Am J Pathol, 140:1375–1388.
15.
PostmaDS, KerlchofM, BoezenHM, KoppelmanGH. 2011. Asthma and chronic obstructive pulmonary disease: common genes, common environments?AJRCCM, 183,12:1588–1594.
16.
RamosC, BecerrilC, MontanoM, Gracia-De-AlbaCet al.2010. FGF-1 reverts epithelial-mesenchymal transition induced by TGF-b1 through MAPK/ERK kinase pathway. Am J Physiol Lung Cell Mol Physiol, 299:L222–L231.
17.
RedingtonAE, MaddenJ, FrewAJet al.1997. Transforming growth factor-beta 1 in asthma—measurement in bronchoalveolar lavage fluid. AJRCCM, 156:642–647.
18.
ShiW, ChenF, CardosoW. 2006. Mechanisms of lung development. Proc Am Thorac Soc, 6:558–563.
19.
ShuklaMN, RoseJL, RayR, LathropKLet al.2009. Hepatocyte growth factor inhibits epithelial to myofibroblast transition in lung cells in SMAD7. Am J Respir Cell Mol Biol, 40:643–653.
WarburtonD, BellusciS. 2004. The molecular genetics of lung morphogenesis and injury repair. Pediatr Respir Rev, 5:S283–S287.
22.
WarburtonD, SchwarzM, TefftD, Flores-DelgadoG, AndersonKD, CardosoWV. 2000. The molecular basis of lung organogenesis. Mech Dev, 92:55–81.
23.
WarburtonD, TefftD, MailleuxA, Bellusciet al.2001. Do lung remodeling, repair and regeneration recapitulate respiratory ontogeny?Am J Respir Crit Care Med, 164:S59–S62.
24.
WeckmannM, TrianT, OliverB. 2009. Reconstruction is not renovation—the role of remodeling in asthma. J Asthma Allergy, 2:33–42.
25.
WeinsteinM, XuX, OhyamaK, DengCX. 1998. FGFR-3 and FGFR-4 function cooperatively to director alveogenesis in the murine lung. Development, 125:3615–3623.
26.
WernerS, GroseR. 2003. Regulation of wound healing by growth factors and cytokines. Physiol Rev, 83,3:835–870.
