Abstract
We compared the antiproliferative effects in vitro of recombinant preparations of interferon-α2c (IFN-α2) and IFN-ω on the formation of colonies from bone marrow progenitor cells. Both IFNs led to statistically indistinguishable dose-dependent inhibitory effects when tested on bone marrow cells derived from 8 normal donors or from 7 patients with chronic myelogenous leukemia (CML). With both IFNs, the cells from CML patients appeared slightly but not significantly more sensitive to inhibition than the cells from normal donors. These results suggest that under some circumstances, IFN-ω may prove an effective treatment for CML, for example, in those becoming resistant to IFN-α2 because of the formation of neutralizing antibodies.
Get full access to this article
View all access options for this article.