Abstract
In this report we show that the mouse interferon (IFN)-γRl and IFN-γR2 subunits expressed in hamster cells are capable of rendering the cells sensitive to mouse IFN-γ as measured by induction of class I MHC antigens and the activation of the transcription factor Stat1α. However, these cells showed no antiviral protection in response to IFN-γ when challenged with vesicular stomatitis virus (VSV) but limited protection when challenged with encephalomyocarditis virus (EMCV). Furthermore, the cytoplasmic domains of the IFN-γR2 subunits, like the cytoplasmic domains of the IFN-γR1 chains, can be interchanged between species with no loss of biologic activity, demonstrating that the species-specific interaction of the IFN-γR1 and IFN-γR2 chains involves only the extracellular domains of the two proteins.
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