Abstract
The initiation of the immune response is regulated, in part, by the effect of cytokines on the level of expression of major histocompatibility complex (MHC) class II antigens on antigen-presenting cells (APC). The expression of class II antigens on B cell and macrophage APC is induced by IFN-γand IL-4, and GM-CSF induces class II expression on macrophages (MФ). Our results show that transforming growth factor-β (TGF-β) inhibits IL-4- and GM-CSF-induced Ia gene expression on bone marrow macrophages but enhances IFN-γ-induced gene expression. Nuclear run-on experiments demonstrated that the inhibitory effects of TGF-β on GM-CSF- and IL-4-induced Ia antigen expression were primarily posttranscriptional and augmentation of IFN-γ by TGF-β was largely transcriptionally regulated.
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