Regulation of Laminin Expression by Interferon

Abstract

Regulation of laminin (LMN) expression by interferon (IFN) treatment has been studied in murine L_B and 3T3 cells, human lung epithelial (A549) and foreskin fibroblast (FS4) cells, and bovine aortic endothelial cells. Using various morphological and biochemical techniques, our data show an increased expression of LMN following IFN treatment, with a corresponding increase in the mRNA levels. These observations may have considerable significance in various phases of wound healing, since exogenous LMN has been shown to increase the migration of epithelial cells and may lead to rapid healing of burn, traumatic, or infectious injuries.