Abstract
A plasmid was constructed to express a mouse β-interferon (IFN-β) in Escherichia coli under the control of the modified tryptophan (trp) promoter. E. coli carrying the plasmid were cultivated in a minijar fermentor and synthesized up to 2.7 × 106 IU/ml of antiviral activity. At the end of the cultivation the cells became elongated and curved.
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