Abstract
Murine splenic lymphocytes cultured for 18 h with either irradiated syngeneic cells infected with influenza A/PR/8/34 virus or irradiated allogeneic cells infected with the same virus release significant quantities of alpha interferon (IFN-α) in 24 h. Uninfected allogeneic cells, which are potent stimulators of both lymphocyte proliferation and cytolytic T lymphocytes, failed to induce detectable level of IFN under the same conditions. Cells derived from naive and virus-primed animals gave similar responses to these stimulae. The phenotype of the cells interacting in vitro to these conditions is discussed.
Get full access to this article
View all access options for this article.