Abstract
The fate of human natural interferons α and β and of recombinant (R) α2 has been investigated by using an isolated and perfused rabbit kidney preparation with a normal physiological performance. A remarkable amount of IFN is filtrated in a monoexponential fashion, reabsorbed and very likely degraded in tubular cells with negligible excretion in the urine. The disappearance rate of HuRIFN-α2 is higher than natural HuIFNs-α and β and is in keeping with the lower molecular weight of RIFN-α2. Differences in molecular charge or shape are probably responsible for the slightly reduced filtration of IFN-β. Pharmacokinetic studies in animal models appear instructive and useful for devicing improved dosage schedules in clinical trials.
Get full access to this article
View all access options for this article.