Abstract
Two patients with extensive warts which were stable for two years or more were treated with human interferon-α to assess the ability of interferon to affect this benign tumor of viral etiology. Intramuscular administration of 96.6 and 135 million units over 12–15 weeks produced softening and decreased scaling of each patient's warts. Double blind, placebo-controled intralesional injections resulted in progressive disappearance of interferon treated warts. A dose response relationship was shown in eight warts. The minimum effective dose was 1.2 × 106 units injected over 15.5 weeks.
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