Abstract
Solid tumors produced in mice by Ehrlich ascites cancer cells were completely regressed by treatment with the copolymer of polyriboinosinic acid-polyribocytidylic acid (poly (I):(C)) when 200 μg of this compound was intravenously injected 3 times a week for 3–4 weeks, starting 7–8 days after transplantation of the tumor. Although the first injection of poly (I):(C) caused hyporeactivity to re-induction of IFN, the subsequent 6 doses stimulated the formation of IFN at 3685 units/ml on average after each injection, strongly suggesting that IFN plays a role in the antitumoral effect of poly (I):(C).
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