Abstract
β and γ interferons were found to enhance the organization of microfilaments, intermediate filaments, and fibronectin in a murine sarcoma virus (MSV)-transformed cell line. Furthermore, both interferons increased the number of intermediate-type junctions. Sodium butyrate was also found to act in a similar way and, when associated with interferon, an additive effect was observed. In a cell line, cultured for many passages in the presence of β interferon (MSV-IF+), the cytoskeletal network and the extra-cellular matrix were highly developed and were reminiscent of a normal cell. These results could explain some of the biological actions of interferon, such as increased cell adhesion to the substratum and decreased cell motility.
Get full access to this article
View all access options for this article.