Despite human exposition to environmental agents such as cadmium (Cd) and use of recreational beverages such as caffeine (Caf), it lacks investigations about their interactions on the central nervous system. This work investigates the effects of Cd+Caf intake on aggression behavior.
Methods:
Adult male Wistar rats received during 4 weeks: water (Ct), Cd solution-50 ppm, and Caf solution-5 ppm. At the end of the treatments, aggression behavior was evaluated using resident–intruder paradigm, and blood and brain were collected for measurement of Cd concentration.
Results:
No differences were observed between groups in water and food intake, and in animal weight gain. Cd levels increased in blood and in brain of animals exposed to Cd and Cd+Caf. Animals exposed to Cd and Caf alone showed no alterations in aggression behavior, while when together showed a significant increase of aggression behavior indicating clearly an effect of interaction due to coexposure.
Conclusion:
The interaction here observed is very worrying and major consequences of this type of coexposure should receive new toxicological considerations.
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