This brief report describes the burden of cancer among adolescents and young adults (AYAs), aged 15–39 years, in Massachusetts from 2004 to 2014 using data from the Massachusetts Cancer Registry and Registry of Vital Records and Statistics. In Massachusetts, 4.6% of cancer cases and 1.3% of cancer deaths occurred among AYAs. The incidence rate of cancer among AYAs was 77.6 cases per 100,000 and the mortality rate was 8.0 deaths per 100,000. The incidence rates of melanoma and Hodgkin lymphoma have been decreasing annually. The incidence rate of thyroid cancer has been increasing for females aged 15–24 years and males aged 25–39 years.
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