Performance of PARI eFlow ® To the Editor

Geller DE , Margaret Rosenfeld , David A. , Waltz , Robert W. , Wilmott . the AeroDose TOBI Study Group. Efficiency of pulmonary administration of tobramycin solution for inhalation in cystic fibrosis using an improved drug delivery system. Chest., 2003; 123:28–36.

Hubert D et al. Pharmacokineric comparison of inhaled tobramycin (TOBI) via PARI eFlow^®rapid or PARI LC^® Plus nebulizers in cystic fibrosis patients. Poster presentation at the ECFC conference in Belek, 2007Abstract in J Cyst Fibrosis6,Suppl. 1:S12The full paper: Pharmacokinetics and safety of tobramycin administered by the PARI eFlow^® rapid nebulizer in cystic fibrosis has recently been published in J Cyst Fibrosis. 2009;6:332–337.]

Mitchell JP , Nagel MW , Nichols S , Nerbrink O . Laser diffractometry as a technique for rapid assessment of aerosol particle size from inhalers. J Aerosol Med., 2006; 19:409–433.

Coates AL , Green M , Leung K , Louca E , Tservistas M , Chan J , Ribeiro N , Charron M . The challenges of quantitative measurement of lung depostion using ⁹⁹Tc-DTPA from delivery systems with very different delivery times. J Aerosol Med, 2007; 20:320–329.

Coates AL , Green M , Leung K , Chan J , Ribeiro N , Louca E , Ratjen F , Charron M , Tservistas M , Keller M . Rapid pulmonary delivery of inhaled tobramycin for pseudomonas infection in cystic fibrosis. Pediatr Pulmonol, 2008; 43:753–759.

Fischer R et al. Inhalation with the PARI eFlow rapid reduces treatment time burden significantly in adult CF patients without altering lung function. Poster presentation at the ECFC conference in Belek, 2008Abstract in J Cyst Fibrosis6,Suppl 1:S41.

Militz S et al. E-Flow rapid: improved lung function and patient satisfaction with more volume delivered to the lungs during inhalation therapy in cystic fibrosis. Poster presented at the ECFC conference in Prague, 2008Abstract in J Cyst Fibrosis7,Suppl. 2:S67.

Bakuridze L , Andrieu V , Dupond C , Dubus JC . Does repeated disinfection of the e-Flow rapid^® nebulizer affect in vitro performance? J Cystic Fibrosis, 2007; 6:309–310.

Perkins WR et al. Aerosolization of liposomal amikacin (Arikace™) using different nebulizers: selection of the eFlow^® nebulizer. Poster presented at the NACF conference in Anaheim, 2007Abstract in Pediatric Pulmonology2007; 42,Suppl. 30:356.