The aim of this work was to optimize microencapsulation process conditions for carotenoids production by yeast Phaffia rhodozyma NRRL Y-17268 by spray drying with xanthan gum (XG) as coating material. Carotenoids production was carried out in shake flasks with initial pH of medium yeast malt (YM) 6.0, 25°C, 180 rpm for 168 h. Carotenogenic extracts were obtained by cell wall rupture via ultrasonic waves (285.71 ug/g). Conditions for maximization of the atomization process were evaluated using a central composite design (CCD, 23 + 3 central points) by evaluating the effects of air temperature (110 to 130°C), feed flow (0.15 to 0.25 g/L) and XG concentration (0.5 to 1.0%) on encapsulation yield. Maximum microencapsulation yield reached 51%, and the addition of the surfactant Tween 80 increased encapsulation efficiency to 70%. Differential scanning calorimetry and Fourier transform infrared spectroscopy analysis confirmed the encapsulation of carotenoids.
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