Cancer-related fatigue (CRF) affects a significant number of cancer survivors both during and after active treatment. CRF may involve emotional, cognitive, and physical fatigue components that significantly affect quality of life. Recommendations for CRF management may include self-care, patient and caregiver education, and both nonpharmacologic and pharmacologic treatment. Because pharmacologic therapy in the treatment of CRF may have limited efficacy, nonpharmacologic options can have an important role for many patients. Diet and exercise may play a part in managing CRF, as may acupuncture, massage, and mind-body therapies. Adaptogenic herbs may also be helpful, and evidence for the use of Withania somnifera, Ganoderma lucidum, and Panax ginseng is also reviewed.
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