Surgical Approaches to Gene and Stem Cell Therapy for Retinal Disease

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References

Birch

D.G.

, Liang

F.Q.

2007. Age-related macular degeneration: a target for nanotechnology derived medicines. Int. J. Nanomedicine, 2:65–77.

Bird

A.C.

, Bressler

N.M.

, Bressler

S.B.

et al. International ARM Epidemiological Study Group. 1995. An international classification and grading system for age-related maculopathy and age-related macular degeneration. Surv. Ophthalmol., 39:367–374.

Blodi

B.A.

2004. Nutritional supplements in the prevention of age-related macular degeneration. Insight, 29:15–16; quiz 17–18.

Bone

R.A.

, Landrum

J.T.

, Guerra

L.H.

, Ruiz

C.A.

2003. Lutein and zeaxanthin dietary supplements raise macular pigment density and serum concentrations of these carotenoids in humans. J. Nutr., 133:992–998.

Bressler

N.M.

2009. Antiangiogenic approaches to age-related macular degeneration today. Ophthalmology, 116:S15–S23.

Bush

R.A.

, Lei

, Tao

et al. 2004. Encapsulated cell-based intraocular delivery of ciliary neurotrophic factor in normal rabbit: Dose-dependent effects on ERG and retinal histology. Invest. Ophthalmol. Vis. Sci., 45:2420–2430.

Enzmann

, Faude

, Wiedemann

, Kohen

2000. The local and systemic secretion of the pro-inflammatory cytokine interleukin-6 after transplantation of retinal pigment epithelium cells in a rabbit model. Curr. Eye Res., 21:530–534.

Enzmann

, Hollborn

, Kuhnhoff

et al. 2002. Influence of interleukin 10 and transforming growth factor-β on T cell stimulation through allogeneic retinal pigment epithelium cells in vitro. Ophthalmic Res., 34:232–240.

Friedman

D.S.

, O'Colmain

B.J.

, Munoz

et al. 2004. Prevalence of age-related macular degeneration in the United States. Arch. Ophthalmol., 122:564–572.

10.

Gamm

D.M.

, Wang

, Lu

et al. 2007. Protection of visual functions by human neural progenitors in a rat model of retinal disease. PLoS One, 2:e338.

11.

Grisanti

, Ishioka

, Kosiewicz

, Jiang

L.Q.

1997. Immunity and immune privilege elicited by cultured retinal pigment epithelial cell transplants. Invest. Ophthalmol. Vis. Sci., 38:1619–1626.

12.

Haddad

, Chen

C.A.

, Santangelo

S.L.

, Seddon

J.M.

2006. The genetics of age-related macular degeneration: A review of progress to date. Surv. Ophthalmol., 51:316–363.

13.

Hou

H.Y.

, Liang

H.L.

, Wang

Y.S.

et al. 2010. A therapeutic strategy for choroidal neovascularization based on recruitment of mesenchymal stem cells to the sites of lesions. Mol. Ther., 18:1837–1845.

14.

Jiang

L.Q.

, Jorquera

, Streilein

J.W.

1993. Subretinal space and vitreous cavity as immunologically privileged sites for retinal allografts. Invest. Ophthalmol. Vis. Sci., 34:3347–3354.

15.

Jiang

L.Q.

, Jorquera

, Streilein

J.W.

1994. Immunologic consequences of intraocular implantation of retinal pigment epithelial allografts. Exp. Eye Res., 58:719–728.

16.

Kaiser

P.K.

2006. Antivascular endothelial growth factor agents and their development: Therapeutic implications in ocular diseases. Am. J. Ophthalmol., 142:660–668.

17.

Klein

, Klein

B.E.

, Tomany

S.C.

et al. 2002. Ten-year incidence and progression of age-related maculopathy: The Beaver Dam Eye Study. Ophthalmology, 109:1767–1779.

18.

Klein

, Peto

, Bird

, Vannewkirk

M.R.

2004. The epidemiology of age-related macular degeneration. Am. J. Ophthalmol., 137:486–495.

19.

Maclachlan

T.K.

, Lukason

, Collins

et al. 2011. Preclinical safety evaluation of AAV2-sFLT01: A gene therapy for age-related macular degeneration. Mol. Ther., 19:326–334.

20.

Redenti

, Tao

, Yang

et al. 2008. Retinal tissue engineering using mouse retinal progenitor cells and a novel biodegradable, thin-film poly(ɛ-caprolactone) nanowire scaffold. J. Ocul. Biol. Dis. Infor., 1:19–29.

21.

Rosenfeld

P.J.

, Brown

D.M.

, Heier

J.S.

et al. 2006a. Ranibizumab for neovascular age-related macular degeneration. N. Engl. J. Med., 355:1419–1431.

22.

Rosenfeld

P.J.

, Rich

R.M.

, Lalwani

G.A.

2006b. Ranibizumab: Phase III clinical trial results. Ophthalmol. Clin. North Am., 19:361–372.

23.

Seddon

J.M.

, Hennekens

C.H.

1994. Vitamins, minerals, and macular degeneration: Promising but unproven hypotheses. Arch. Ophthalmol., 112:176–179.

24.

Seiler

M.J.

, Aramant

R.B.

2005. Transplantation of neuroblastic progenitor cells as a sheet preserves and restores retinal function. Semin. Ophthalmol., 20:31–42.

25.

Seiler

M.J.

, Rao

, Aramant

R.B.

et al. 2010. Three-dimensional optical coherence tomography imaging of retinal sheet implants in live rats. J. Neurosci. Methods, 188:250–257.

26.

Sieving

P.A.

, Caruso

R.C.

, Tao

et al. 2006. Ciliary neurotrophic factor (CNTF) for human retinal degeneration: Phase I trial of CNTF delivered by encapsulated cell intraocular implants. Proc. Natl. Acad. Sci. U.S.A., 103:3896–3901.

27.

Sodha

, Wall

, Redenti

et al. 2011. Microfabrication of a three-dimensional polycaprolactone thin-film scaffold for retinal progenitor cell encapsulation. J. Biomater. Sci. Polym. Ed., 22:443–456.

28.

Steedman

M.R.

, Tao

S.L.

, Klassen

, Desai

T.A.

2010. Enhanced differentiation of retinal progenitor cells using microfabricated topographical cues. Biomed. Microdevices, 12:363–369.

29.

Stone

E.M.

2006. A very effective treatment for neovascular macular degeneration. N. Engl. J. Med., 355:1493–1495.

30.

Sugino

I.K.

, Sun

, Wang

et al. 2011. Comparison of fetal RPE and human embryonic stem cell derived-RPE (hES-RPE) behavior on aged human Bruch's membrane. Invest. Ophthalmol. Vis. Sci.(in press).

31.

Tao

, Young

, Redenti

et al. 2007. Survival, migration and differentiation of retinal progenitor cells transplanted on micro-machined poly(methyl methacrylate) scaffolds to the subretinal space. Lab on a Chip, 7:695–701.

32.

Tomita

, Lavik

, Klassen

et al. 2005. Biodegradable polymer composite grafts promote the survival and differentiation of retinal progenitor cells. Stem Cells, 23:1579–1588.

33.

Umeda

, Suzuki

M.T.

, Okamoto

et al. 2005. Molecular composition of drusen and possible involvement of anti-retinal autoimmunity in two different forms of macular degeneration in cynomolgus monkey (Macaca fascicularis) FASEB J., 19:1683–1685.

34.

Yao

, Tucker

B.A.

, Zhang

et al. 2011. Robust cell integration from co-transplantation of biodegradable MMP2-PLGA microspheres with retinal progenitor cells. Biomaterials, 32:1041–1050.

35.

Zhang

, Hopkins

J.J.

, Heier

J.S.

et al. 2011. Ciliary neurotrophic factor delivered by encapsulated cell intraocular implants for treatment of geographic atrophy in age-related macular degeneration. Proc. Natl. Acad. Sci. U.S.A.(in press).