Acetazolamide for the Prevention of Acute Mountain Sickness: Time to Move On

Brok J , Thorlund K , Wetterslev J , Gluud C . 2009. Apparently conclusive meta-analyses may be inconclusive. Trial sequential analysis adjustment of random error risk due to repetitive testing of accumulating data in apparently conclusive neonatal meta-analyses. Int J Epidemiol, 38:287–298.

Higgins JPT , Green S . 2011. Cochrane Handbook for Systematic Reviews of Interventions.Version 5.1.0. Chapter 8 www.cochrane-handbook.org.

Kayser B , Dumont L , Lysakowski C , Combescure C , Haller G , Tramèr MR . 2012. Reappraisal of acetazolamide for the prevention of acute mountain sickness: A systematic review and meta-analysis. High Alt Med Biol, 13:82–92.

Wetterslev J , Thorlund K , Brok J , Gluud C . 2008. Trial sequential analysis may establish when firm evidence is reached in cumulative meta-analysis. J Clin Epidemiol, 61:64–75.

Wetterslev J , Thorlund K , Brok J , Gluud C . 2009. Estimating required information size by quantifying diversity in random-effects model meta-analyses. BMC Med Res Methodol, 9:86.

Thorlund K , Imberger G , Walsh M , Chu R , Gluud C , Wetterslev J , Guyatt G , Devereaux PJ , Thabane L . 2011. The number of patients and events required to limit the risk of overestimation of intervention effects in meta-analysis—A simulation study. PLoS One, 6:e25491.