Abstract
Abstract
Objectives:
Ovarian carcinosarcomas are rare and aggressive ovarian malignancies. The objective of this study was to examine the current authors' experiences with optimal cytoreductive surgery (CRS) and platinum-based chemotherapy for managing ovarian carcinosarcomas.
Materials and Methods:
A retrospective study was carried out on 20 patients who had ovarian carcinosarcoma (OCS) and who underwent primary surgery at the Rajiv Gandhi Cancer Institute and Research Centre, in Delhi, India, from January 2004 till December 2016.
Results:
Complete cytoreduction to no gross residual disease was achieved in 14 patients, 10 patients had heterologous histologies with sarcomatous components, and 13 patients had advanced stage (stages III and IV) disease. Fifteen patients received platinum-based adjuvant chemotherapy. Follow-up periods ranged from 15 days to 82 months. After primary surgery, 9 patients developed recurrences and 4 had progressive disease. Ten patients died of disease during the follow-up period. The 3-year disease-free survival was 33%, and the 3-year overall survival (OS) was 40.52%. Homologous histology with sarcomatous components and optimal CRS were associated with significant improvements in OS, in a univariate analysis. However, in a multivariate analysis, only optimal surgery retained significance.
Conclusions:
Radical surgery resulting in no visible disease, followed by platinum-based chemotherapy appears to improve outcomes and survival in patients with OCS.
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